The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge.
The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge.
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药物遗传学和药物基因组学知识库：加强知识。
DOI：
10.1093/nar/gkm1009
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Klein, Teri E.
中科院分区：
文献类型：
--
作者：
Hernandez-Boussard, Tina;Whirl-Carrillo, Michelle;Hebert, Joan M.;Gong, Li;Owen, Ryan;Gong, Mei;Gor, Winston;Liu, Feng;Truong, Chuong;Whaley, Ryan;Woon, Mark;Zhou, Tina;Altman, Russ B.;Klein, Teri E.
PharmGKB是一个知识库，捕获药物，疾病/表型和涉及药代动力学（PK）和药效学（PD）的基因之间的关系。这些信息包括文献注释、原始数据集、PK和PD途径，以及专家生成的药物、疾病/表型和基因之间PK/PD关系的摘要。PharmGKB的网站旨在有效地传播知识，以满足用户的需求。PharmGKB目前有文献注释，记录了500多种药物、450种疾病和600种变异基因之间的关系。为了满足全基因组研究的需要，PharmGKB增加了新的功能，包括通过染色体和细胞遗传学位置浏览变异显示，允许用户查看不在基因内的变异。我们已经开发了处理全基因组数据的新基础设施，包括增加的质量控制方法和跨其他数据源（如dbSNP、JSNP和HapMap数据）进行比较的工具。PharmGKB还增加了接受、存储、显示和查询高通量SNP阵列数据的功能。这些变化使我们能够捕获更多关于表型的结构化信息，以便更好地编目和比较数据。PharmGKB可在www.pharmgkb.org上获得
PharmGKB is a knowledge base that captures the relationships between drugs, diseases/phenotypes and genes involved in pharmacokinetics (PK) and pharmacodynamics (PD). This information includes literature annotations, primary data sets, PK and PD pathways, and expert-generated summaries of PK/PD relationships between drugs, diseases/phenotypes and genes. PharmGKB's website is designed to effectively disseminate knowledge to meet the needs of our users. PharmGKB currently has literature annotations documenting the relationship of over 500 drugs, 450 diseases and 600 variant genes. In order to meet the needs of whole genome studies, PharmGKB has added new functionalities, including browsing the variant display by chromosome and cytogenetic locations, allowing the user to view variants not located within a gene. We have developed new infrastructure for handling whole genome data, including increased methods for quality control and tools for comparison across other data sources, such as dbSNP, JSNP and HapMap data. PharmGKB has also added functionality to accept, store, display and query high throughput SNP array data. These changes allow us to capture more structured information on phenotypes for better cataloging and comparison of data. PharmGKB is available at www.pharmgkb.org
影响因子：
14.9
作者：
Hewett, M;Oliver, DE;Klein, TE
通讯作者：
Klein, TE