Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF-α Therapy and Their Correlations with Treatment Outcomes.
Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF-α Therapy and Their Correlations with Treatment Outcomes.
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DOI：
10.1155/2021/1017938
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发表时间：
2021
影响因子：
4.1
通讯作者：
Shi G
中科院分区：
文献类型：
--
作者：
Chen R;Qian H;Yuan X;Chen S;Liu Y;Wang B;Shi G
肿瘤坏死因子-α（TNF-α）抑制剂是生物常规合成缓解病情抗风湿药物的主要类型，对治疗对非甾体抗炎药不敏感的强直性脊柱炎（AS）具有疗效。然而，TNF-α抑制剂对AS患者免疫细胞的影响仍不清楚，免疫细胞对治疗反应的影响也很大程度上难以捉摸。本研究旨在评估抗 TNF-α 治疗后循环免疫细胞的纵向变化及其与 AS 患者治疗反应的关系。 35 名接受抗 TNF-α 治疗的 AS 患者被纳入这项前瞻性观察研究。通过流式细胞术测量基线和治疗后4个时间点外周血中免疫细胞的频率，包括Th1、Th2、Th17、调节性T细胞（Treg）、滤泡辅助性T细胞（Tfh）和调节性B细胞（Breg）。比较了应答者和无应答者之间循环免疫细胞的差异。这项研究表明，抗 TNF-α 疗法可以显着减少循环促炎性免疫细胞，如 Th17 和 Tfh，但显着增加循环 Treg 和 Breg 的百分比。此外，循环 Breg 可能是 AS 患者抗 TNF-α 治疗反应的有希望的预测因子。
Tumor necrosis factor-α (TNF-α) inhibitors are the main types of biological conventional synthetic disease-modifying antirheumatic drugs and have efficacy in treating ankylosing spondylitis (AS) which is not sensitive for nonsteroidal anti-inflammatory drug. However, the impact of TNF-α inhibitors on immune cells in patients with AS is still clearly undefined, and the impact of immune cells on treatment response is also largely elusive. This study is aimed at evaluating the longitudinal changes of circulating immune cells after anti-TNF-α therapy and their associations with treatment response in AS patients. Thirty-five AS patients receiving the treatment of anti-TNF-α therapy were included into this prospective observational study. The frequencies of immune cells including Th1, Th2, Th17, regulatory T cell (Treg), T follicular helper cell (Tfh), and regulatory B cell (Breg) in the peripheral blood were measured by flow cytometry at baseline and 4 time points after therapy. The difference in the circulating immune cells between responders and nonresponders was compared. This study suggested that anti-TNF-α therapy could significantly reduce circulating proinflammatory immune cells such as Th17 and Tfh, but significantly increased the percentages of circulating Treg and Breg. Moreover, circulating Breg may be a promising predictor of response to anti-TNF-α therapy in AS patients.
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