Identification of novel prognosis-related genes in the endometrial cancer immune microenvironment.
Identification of novel prognosis-related genes in the endometrial cancer immune microenvironment.
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子宫内膜癌免疫微环境中新型预后相关基因的鉴定
DOI：
10.18632/aging.104083
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发表时间：
2020-11-06
期刊：
影响因子：
--
通讯作者：
Ma XX
中科院分区：
文献类型：
--
作者：
Ma J;Zhang JK;Yang D;Ma XX
子宫内膜癌的发病率每年都在增加，对于晚期和特定亚型的患者治疗效果较差。探索子宫内膜癌免疫浸润相关因素有助于患者的预后，并提供新的免疫治疗靶点。我们从The Cancer Genome Atlas数据库下载了不同亚型子宫内膜癌患者的免疫元基因和功能数据，并选择淋巴细胞特异性激酶（LCK）元基因作为子宫内膜癌免疫微环境的代表性遗传标记。结果表明，LCK多基因表达与子宫内膜腺癌各亚型患者的预后有关，且与PTEN和PIK 3CA突变状态高度相关。对LCK相关模块的搜索返回了7个子宫内膜癌患者生存的独立遗传预测因子。TIMER算法显示，这7个基因的表达与6种免疫细胞的浸润水平呈正相关。这些标志物的诊断价值进行了验证，使用实时定量PCR和免疫组化方法。结果表明，CD 74、HLA-DRB 5、CD 52、HLA-DPB 1和HLA-DRB 1可能是子宫内膜癌诊断和预后的有价值的遗传标志物，并为子宫内膜癌的临床治疗提供了免疫治疗靶点的理论依据。
The incidence of endometrial cancer is increasing each year, and treatment effects are poor for patients with advanced and specific subtypes. Exploring immune infiltration-related factors in endometrial cancer can aid in the prognosis of patients and provide new immunotherapy targets. We downloaded immune metagene and functional data of patients with different subtypes of endometrial cancer from The Cancer Genome Atlas database and selected the lymphocyte-specific kinase (LCK) metagene as a representative genetic marker of the immune microenvironment in endometrial cancer. The results showed that LCK metagene expression is related to the prognosis of patients with endometrioid endometrial adenocarcinoma subtypes and highly correlated with the PTEN and PIK3CA mutational status. A search for LCK-related modules returned seven independent genetic predictors of survival in patients with endometrial cancer. The TIMER algorithm showed that the expression of these seven genes was positively correlated with the infiltration levels of six types of immune cells. The diagnostic value of these markers was validated using real-time quantitative PCR and immunohistochemical methods. Our results identified CD74, HLA-DRB5, CD52, HLA-DPB1 and HLA-DRB1 as possible valuable genetic markers for the diagnosis and prognosis of endometrial cancer and provided a theoretical basis for immunotherapy targets for its clinical treatment.
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休眠抗肿瘤免疫的重新激活——治疗性免疫检查点调节的临床视角。
DOI：
10.1186/s12964-016-0155-9
发表时间：
2017-01-19
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Greil R;Hutterer E;Hartmann TN;Pleyer L
通讯作者：
Pleyer L
影响因子：
4.7
作者：
Grzankowski, Kassondra S.;Shimizu, David M.;Terada, Keith Y.
通讯作者：
Terada, Keith Y.
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
DOI：
10.1007/978-3-030-36667-4_3
发表时间：
2020-01-01
期刊：
TUMOR MICROENVIRONMENT: THE ROLE OF CHEMOKINES, PT A
影响因子：
--
作者：
Mukaida, Naofumi;Sasaki, So-ichiro;Baba, Tomohisa
通讯作者：
Baba, Tomohisa
影响因子：
11.5
作者：
Gulati, Pratiksha;Ruhl, Julia;Petrausch, Ulf
通讯作者：
Petrausch, Ulf