Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women.
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women.
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DOI：
10.1371/journal.pone.0088455
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Balmes JR
中科院分区：
文献类型：
--
作者：
Guarnieri MJ;Diaz JV;Basu C;Diaz A;Pope D;Smith KR;Smith-Sivertsen T;Bruce N;Solomon C;McCracken J;Balmes JR
超过五分之二的世界人口使用固体燃料，主要是生物质，用于烹饪。由此产生的生物质烟雾暴露是发展中国家妇女患慢性阻塞性肺病的主要原因。评估与明火相比，使用有烟囱的炉子产生的较低的木烟暴露是否与年轻女性较低的气道炎症标志物相关。我们对参加危地马拉农村随机对照试验的参与者进行了横断面分析。在18个月的试验结束时，我们招募了45名土著妇女; 19名妇女已经使用烟囱炉18-24个月，26名妇女仍然使用明火。我们获得肺功能测定和诱导痰细胞计数，IL-8，TNF-α，MMP-9和12的基因表达，以及IL-8，髓过氧化物酶和纤维连接蛋白的蛋白浓度。测量呼出的一氧化碳（CO）和48小时个人CO管，以评估烟雾暴露。MMP-9基因表达在使用烟囱炉的妇女中显着降低。较高的呼出CO浓度与IL-8、TNF-α和MMP-9的较高基因表达显著相关。较高的48小时个人CO浓度与IL-8、TNF- α、MMP-9和MMP-12的较高基因表达相关; MMP-9和MMP-12达到统计学显著性。与使用明火做饭相比，使用烟囱炉与MMP-9基因表达降低相关，MMP-9是气道重塑的潜在介质。在所有参与者中，室内生物质烟雾暴露与气道炎症和重塑的多种介质的较高基因表达相关;这些机制可以解释长期生物质烟雾暴露与COPD之间的一些观察到的关联。
More than two-fifths of the world’s population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries. To assess whether lower woodsmoke exposure from use of a stove with a chimney, compared to open fires, is associated with lower markers of airway inflammation in young women. We carried out a cross-sectional analysis on a sub-cohort of participants enrolled in a randomized controlled trial in rural Guatemala, RESPIRE. We recruited 45 indigenous women at the end of the 18-month trial; 19 women who had been using the chimney stove for 18–24 months and 26 women still using open fires. We obtained spirometry and induced sputum for cell counts, gene expression of IL-8, TNF-α, MMP-9 and 12, and protein concentrations of IL-8, myeloperoxidase and fibronectin. Exhaled carbon monoxide (CO) and 48-hr personal CO tubes were measured to assess smoke exposure. MMP-9 gene expression was significantly lower in women using chimney stoves. Higher exhaled CO concentrations were significantly associated with higher gene expression of IL-8, TNF-α, and MMP-9. Higher 48-hr personal CO concentrations were associated with higher gene expression of IL-8, TNF- α, MMP-9 and MMP-12; reaching statistical significance for MMP-9 and MMP-12. Compared to using an open wood fire for cooking, use of a chimney stove was associated with lower gene expression of MMP-9, a potential mediator of airway remodeling. Among all participants, indoor biomass smoke exposure was associated with higher gene expression of multiple mediators of airway inflammation and remodeling; these mechanisms may explain some of the observed association between prolonged biomass smoke exposure and COPD.
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影响因子：
10.4
作者：
Bonjour S;Adair-Rohani H;Wolf J;Bruce NG;Mehta S;Prüss-Ustün A;Lahiff M;Rehfuess EA;Mishra V;Smith KR
通讯作者：
Smith KR
DOI：
10.1164/ajrccm.156.1.9612018
发表时间：
1997-07-01
影响因子：
24.7
作者：
Finlay, GA;ODriscoll, LR;OConnor, CM
通讯作者：
OConnor, CM
影响因子：
9.6
作者：
Dennis, RJ;Maldonado, D;Martinez, G
通讯作者：
Martinez, G
影响因子：
5.1
作者：
Banerjee, Anirban;Mondal, Nandan Kumar;Ray, Manas Ranjan
通讯作者：
Ray, Manas Ranjan
影响因子：
4.3
作者：
DOSSING, M;KHAN, J;ALRABIAH, F
通讯作者：
ALRABIAH, F