Involvement of prostaglandin E2 synthesis in the intestinal secretory action of Escherichia coli heat-stable enterotoxin II.
Involvement of prostaglandin E2 synthesis in the intestinal secretory action of Escherichia coli heat-stable enterotoxin II.
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前列腺素 E2 合成参与大肠杆菌热稳定肠毒素 II 的肠道分泌作用。
DOI：
10.1111/j.1574-6968.1995.tb07729.x
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发表时间：
1995
影响因子：
2.1
通讯作者：
Keinosuke Okamoto
中科院分区：
文献类型：
--
作者：
Y. Fujii;Yukiko Kondo;Keinosuke Okamoto
研究了大肠杆菌耐热肠毒素II对小鼠肠上皮细胞前列腺素的影响。肠细胞产生的前列腺素E2的量与热稳定肠毒素II的剂量直接相关。前列腺素E2量随时间的变化与释放到肠腔中的液体量相关。然后，我们证明，热稳定肠毒素II到小鼠肠循环的管理引起的花生四烯酸和磷脂酸水平的肠上皮细胞的升高。这些结果表明，热稳定的肠毒素II刺激花生四烯酸在肠上皮细胞的代谢和合成的前列腺素E2的功能作为介体的液体分泌诱导这种肠毒素。
The prostaglandin response of mouse intestinal epithelial cells after exposure to Escherichia coli heat-stable enterotoxin II was examined. The quantity of prostaglandin E2 produced by the intestinal cells was directly related to the dose of heat-stable enterotoxin II. The change in the amount of prostaglandin E2 over time correlated to that of the volume of fluid released into the intestinal lumen. We then demonstrated that administration of heat-stable enterotoxin II into the intestinal loops of mice induced elevation of arachidonic acid and phosphatidic acid levels in intestinal epithelial cells. These results show that heat-stable enterotoxin II stimulates arachidonic acid metabolism in intestinal epithelial cells and that the synthesized prostaglandin E2 functions as a mediator of fluid secretion induced by this enterotoxin.
前列腺素合成与离体大鼠肾小球中磷脂酰肌醇周转有关。
DOI：
10.1016/0005-2760(84)90147-4
发表时间：
1984
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Folkert,VW;Yunis,M;Schlondorff,D
通讯作者：
Schlondorff,D
影响因子：
56.9
作者：
GABRIEL, SE;BRIGMAN, KN;STUTTS, MJ
通讯作者：
STUTTS, MJ