Posttranslational regulation of surfactant protein B expression.
Posttranslational regulation of surfactant protein B expression.
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DOI：
10.1053/j.semperi.2008.08.003
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发表时间：
2008-10
影响因子：
3.4
通讯作者：
Guttentag, Susan
中科院分区：
文献类型：
--
作者：
Guttentag, Susan
Though a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contributing to the formation of lamellar bodies. SP-B production is a complex process within alveolar type 2 cells, and is under hormonal and developmental control. Understanding the post-translational events in the maturation of SP-B may provide new insight into the process of lamellar body formation and into the pathophysiology of pulmonary disorders associated with surfactant abnormalities.
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影响因子：
4.8
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