Oxidative Stress and Inflammation in SARS-CoV-2- and Chlamydia pneumoniae-Associated Cardiovascular Diseases.

Oxidative Stress and Inflammation in SARS-CoV-2- and Chlamydia pneumoniae-Associated Cardiovascular Diseases.
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DOI:
10.3390/biomedicines9070723
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发表时间:
2021-06-24
期刊:
影响因子:
4.7
通讯作者:
Sessa R
Sessa R
中科院分区:
工程技术3区
文献类型:
--
作者:
Filardo S;Di Pietro M;Diaco F;Romano S;Sessa R

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多年来,越来越多的研究提供了证据,表明氧化应激和炎症可能参与传染源相关心血管疾病的发病机制。在众多呼吸道病原体中,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)(一种导致全球持续大流行的新型冠状病毒)和肺炎衣原体(一种众所周知的细胞内专性细菌)似乎在促进活性氧和细胞因子产生方面发挥着重要作用。本综述强调了与 SARS-CoV-2 或肺炎衣原体感染相关的心血管疾病的常见氧化和炎症分子途径。还将讨论使用天然抗氧化剂化合物的主要治疗和预防方法。
Throughout the years, a growing number of studies have provided evidence that oxidative stress and inflammation may be involved in the pathogenesis of infectious agent-related cardiovascular diseases. Amongst the numerous respiratory pathogens, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus responsible for the global ongoing pandemic, and Chlamydia pneumoniae, a widely known intracellular obligate bacteria, seem to have an essential role in promoting reactive oxygen species and cytokine production. The present review highlights the common oxidative and inflammatory molecular pathways underlying the cardiovascular diseases associated with SARS-CoV-2 or C. pneumoniae infections. The main therapeutic and preventive approaches using natural antioxidant compounds will be also discussed.
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