Hormone replacement therapy before breast cancer diagnosis significantly reduces the overall death rate compared with never-use among 984 breast cancer patients.
Hormone replacement therapy before breast cancer diagnosis significantly reduces the overall death rate compared with never-use among 984 breast cancer patients.
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DOI：
10.1038/sj.bjc.6690543
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发表时间：
1999-07
影响因子：
8.8
通讯作者：
Olsson, H
中科院分区：
文献类型：
--
作者：
Jernström, H;Frenander, J;Fernö, M;Olsson, H
984例乳腺癌患者接受了关于外源性激素使用的采访。这代表了瑞典南部乳腺癌患者的随机样本，这些患者在1978年至1997年（不包括1980年和1981年）期间转诊至隆德肿瘤科接受治疗，并进行了100%随访。在45岁及以上诊断为乳腺癌的妇女中，诊断前经常使用激素替代疗法（HRT）与总生存期延长显著相关，死亡的相对危险度（RR）为0.73（95%置信区间（CI）为0.62-0.87; P = 0.0005）。在调整T分期、N分期、M分期、诊断年份和诊断时年龄后，乳腺癌诊断前曾使用HRT与总生存期延长显著正相关，死亡RR为0.78（95%CI 0.65-0.93; P = 0.006）。在一个模型中，激素替代疗法的使用和雌激素受体阳性与总体生存期延长独立显著相关，分别为P = 0.005和P < 0.0001。在另一个模型中，HRT的使用和孕激素受体阳性也与较长的总生存期独立显著相关，分别为P = 0.003和P = 0.0003。705名妇女的诊断模式是已知的。乳腺X线筛查在HRT使用者中并不比从未使用者更常见，在这些信息可用的情况下。乳腺X线筛查和HRT的使用与较长的生存期独立相关，分别为P = 0.002和P = 0.038。© 1999癌症研究运动
Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-use of hormone replacement therapy (HRT) prior to diagnosis was significantly associated with a longer overall survival in women with their breast cancer diagnosed at ages 45 and above, relative risk (RR) of dying 0.73 (95% confidence interval (CI) 0.62–0.87; P = 0.0005). Ever use of HRT prior to breast cancer diagnosis was significantly positively associated with overall longer survival after adjustment for T-stage, N-stage, M-stage, year of diagnosis and age at diagnosis, RR of dying 0.78 (95% CI 0.65–0.93; P = 0.006). Hormone replacement therapy use and oestrogen receptor positivity were independently significantly associated with overall longer survival, P = 0.005 and P < 0.0001, respectively, in one model. HRT use and progesterone receptor positivity were also independently significantly associated with longer overall survival, P = 0.003 and P = 0.0003, respectively, in another model. The mode of diagnosis was known in 705 women. Mammography screening was not more common among HRT users compared with never-users, where this information was available. Both mammography screening and HRT use were independently associated with longer survival, P = 0.002 and P = 0.038 respectively. © 1999 Cancer Research Campaign
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影响因子：
2.3
作者：
Willis, DB;Calle, EE;Heath, CW
通讯作者：
Heath, CW
影响因子：
168.9
作者：
NYSTROM, L;RUTQVIST, LE;LARSSON, LG
通讯作者：
LARSSON, LG
DOI：
10.3109/02841868609136398
发表时间：
1986-05-01
期刊：
ACTA RADIOLOGICA ONCOLOGY
影响因子：
--
作者：
FERNO, M;BORG, A;SELLBERG, G
通讯作者：
SELLBERG, G
影响因子：
2.3
作者：
YUEN, J;PERSSON, I;ADAMI, HO
通讯作者：
ADAMI, HO
影响因子：
158.5
作者：
SIGURDSSON, H;BALDETORP, B;OLSSON, H
通讯作者：
OLSSON, H