The association between sedentary behaviour, physical activity and type 2 diabetes markers: A systematic review of mixed analytic approaches.
The association between sedentary behaviour, physical activity and type 2 diabetes markers: A systematic review of mixed analytic approaches.
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DOI：
10.1371/journal.pone.0268289
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
久坐行为对2型糖尿病标志物的负面影响已经确立，但与体力活动措施的相互作用在很大程度上仍然未知。以前的研究分析了与单一活动模型的关联，忽略了与其他行为的相互作用。通过包括从各种分析方法的结果，这篇评论批判性地总结了久坐行为对糖尿病标志物的影响，以及身体活动的替代和组成的好处。系统检索了奥维德Medline、Embase和科克伦图书馆数据库。如果在一般人群中通过加速度计测量久坐行为和体力活动，并且如果报告了与葡萄糖、胰岛素、HOMA-IR、胰岛素敏感性、HbA 1c、糖尿病发病率、CRP和IL-6的相关性，则选择研究。45项研究被纳入审查。确定了2小时胰岛素（6/12项研究发现相关性）、空腹胰岛素（15/19项研究）、胰岛素敏感性（4/6项研究）、糖尿病（3/4项研究）和IL-6（2/3项研究）与久坐行为的结论性有害关联。将久坐行为重新分配为轻度或中度至剧烈活动对2小时血糖（1/1研究）、空腹胰岛素（3/3研究）、HOMA-IR（1/1研究）和胰岛素敏感性（1/1研究）具有有益影响。久坐行为的成分测量被发现影响2小时血糖（1/1研究）、空腹胰岛素（2/3研究）、2小时胰岛素（1/1研究）、HOMA-IR（2/2研究）和CRP（1/1研究）。不同的分析方法对空腹血糖、2小时血糖、2小时胰岛素、胰岛素敏感性、HOMA-IR、糖尿病、HbA 1c、CRP和IL-6产生了相互矛盾的结果。通过四分位数分析数据的研究报告了久坐行为与空腹胰岛素、HOMA-IR和糖尿病之间的独立相关性，仅针对久坐时间长的情况（7-9小时/天）。然而，这项综述无法提供足够的证据来证明糖尿病生物标志物久坐行为的时间特异性截止。虽然用中度到剧烈的活动取代久坐行为会带来更大的健康改善，但轻度活动也有利于代谢健康。未来的研究应阐明替代和结合不同的活动持续时间和方式的影响。
The negative effect of sedentary behaviour on type 2 diabetes markers is established, but the interaction with measures of physical activity is still largely unknown. Previous studies have analysed associations with single-activity models, which ignore the interaction with other behaviours. By including results from various analytical approaches, this review critically summarises the effects of sedentary behaviour on diabetes markers and the benefits of substitutions and compositions of physical activity. Ovid Medline, Embase and Cochrane Library databases were systematically searched. Studies were selected if sedentary behaviour and physical activity were measured by accelerometer in the general population, and if associations were reported with glucose, insulin, HOMA-IR, insulin sensitivity, HbA1c, diabetes incidence, CRP and IL-6. Forty-five studies were included in the review. Conclusive detrimental associations with sedentary behaviour were determined for 2-h insulin (6/12 studies found associations), fasting insulin (15/19 studies), insulin sensitivity (4/6 studies), diabetes (3/4 studies) and IL-6 (2/3 studies). Reallocating sedentary behaviour to light or moderate-to-vigorous activity has a beneficial effect for 2-h glucose (1/1 studies), fasting insulin (3/3 studies), HOMA-IR (1/1 studies) and insulin sensitivity (1/1 studies). Compositional measures of sedentary behaviour were found to affect 2-h glucose (1/1 studies), fasting insulin (2/3 studies), 2-h insulin (1/1 studies), HOMA-IR (2/2 studies) and CRP (1/1 studies). Different analytical methods produced conflicting results for fasting glucose, 2-h glucose, 2-h insulin, insulin sensitivity, HOMA-IR, diabetes, hbA1c, CRP and IL-6. Studies analysing data by quartiles report independent associations between sedentary behaviour and fasting insulin, HOMA-IR and diabetes only for high duration of sedentary time (7–9 hours/day). However, this review could not provide sufficient evidence for a time-specific cut-off of sedentary behaviour for diabetes biomarkers. While substituting sedentary behaviour with moderate-to-vigorous activity brings greater improvements for health, light activity also benefits metabolic health. Future research should elucidate the effects of substituting and combining different activity durations and modalities.
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影响因子：
37.8
作者：
Diaz KM;Goldsmith J;Greenlee H;Strizich G;Qi Q;Mossavar-Rahmani Y;Vidot DC;Buelna C;Brintz CE;Elfassy T;Gallo LC;Daviglus ML;Sotres-Alvarez D;Kaplan RC
通讯作者：
Kaplan RC
影响因子：
4.1
作者：
Farrahi V;Kangas M;Walmsley R;Niemelä M;Kiviniemi A;Puukka K;Collings PJ;Korpelainen R;Jämsä T
通讯作者：
Jämsä T
影响因子：
8.3
作者：
Ekblom-Bak, Elin;Ekblom, Orjan;Borjesson, Mats
通讯作者：
Borjesson, Mats
影响因子：
7.7
作者：
Balkau, Beverley;Mhamdi, Leila;Ferrannini, Ele
通讯作者：
Ferrannini, Ele
影响因子：
2.3
作者：
Augustin, Nicole H.;Mattocks, Calum;Ness, Andy R.
通讯作者：
Ness, Andy R.