Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands.
Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands.
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使用胺封端配体调节金纳米颗粒的催化活性
DOI：
10.1039/d1sc05933e
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发表时间：
2022-01-26
期刊：
影响因子：
8.4
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Zhang J;Huang Z;Xie Y;Jiang X
纳米酶在治疗诊断和护理点测试中具有广泛的应用。为了增强纳米酶的催化活性，传统的策略是掺杂金属形成高活性的纳米合金。然而，高质量且稳定的纳米合金很难合成。配体修饰是通过改变表面化学来实现化学选择性或生物活性的强大策略。在这里，我们探索不同的配体来增强纳米酶的催化活性，例如金纳米颗粒（AuNP）。我们系统地研究了表面化学配体工程（电荷、基团和表面距离）对金纳米粒子酶活性的影响。我们的工作为纳米酶的表面修饰建立了关键指南。与其他基团相比，胺基团有利于金纳米粒子更高的活性。与其他配体和未修饰的 AuNP 相比，灵活的富含胺的配体增强了 AuNP 的催化活性。使用概念验证模型，我们筛选了许多候选配体以获得多胺-AuNP，与未修饰的AuNP相比，其具有强烈增强的过氧化物酶样活性，并且灵敏度提高了100倍。使用配体增强AuNPs催化活性的策略将促进纳米酶在生物学和诊断学中与催化相关的应用。表面配体工程可以精确调节纳米酶的催化活性，从无活性到高活性。
Nanozymes have broad applications in theranostics and point-of-care tests. To enhance the catalytic activity of nanozymes, the conventional strategy is doping metals to form highly active nanoalloys. However, high-quality and stable nanoalloys are hard to synthesize. Ligand modification is a powerful strategy to achieve chemoselectivity or bioactivity by changing the surface chemistry. Here, we explore different ligands to enhance the catalytic activity of nanozymes, e.g., gold nanoparticles (AuNPs). We systematically studied the impacts on the enzymatic activity of AuNPs by ligand engineering of surface chemistry (charge, group, and surface distance). Our work established critical guidelines for surface modification of nanozymes. The amine group favors higher activity of AuNPs than other groups. The flexible amine-rich ligand enhances the catalytic activity of AuNPs in contrast to other ligands and unmodified AuNPs. Using a proof-of-concept model, we screened many candidate ligands to obtain polyamine-AuNPs, which have strongly enhanced peroxidase-like activity and 100 times enhanced sensitivity compared to unmodified AuNPs. The strategy of enhancing the catalytic activity of AuNPs using ligands will facilitate the catalysis-related applications of nanozymes in biology and diagnostics. Surface ligand engineering can precisely modulate the catalytic activity of nanozymes from inactive to highly active.
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