Early patterning followed by tissue growth establishes distal identity in Drosophila Malpighian tubules.
Early patterning followed by tissue growth establishes distal identity in Drosophila Malpighian tubules.
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DOI：
10.3389/fcell.2022.947376
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发表时间：
2022
影响因子：
5.5
通讯作者：
Denholm, Barry
中科院分区：
文献类型：
--
作者：
Beaven, Robin;Denholm, Barry
关键词：
身体内结构或组织的近端-远端（P-D）轴的规范和细化从身体的主轴的规范和细化次要地发生。我们对P-D轴模式的机制的理解仅限于少数例子，例如脊椎动物和无脊椎动物的肢体。果蝇Malpighian/renal tubules（MpTs）是简单的上皮小管，具有确定的P-D轴。该轴如何被图案化是未知的，并且提供了理解次轴的图案化机制的理想背景。此外，上皮小管分布广泛，其模式尚不清楚。在这里，我们描述了建立远端小管的机制，并表明这是一个完全不同的机制，图案的近端MpT。远端结构域分两步形成模式：远端身份在MpT发育早期的一小群细胞中通过Wingless/Wnt信号传导被指定。随后，通过增殖扩增该群体以产生远端MpT结构域。这种机制使远端身份能够在小管中建立在一个比Wingless的有效范围大得多的细胞域中。
Specification and elaboration of proximo-distal (P-D) axes for structures or tissues within a body occurs secondarily from that of the main axes of the body. Our understanding of the mechanism(s) that pattern P-D axes is limited to a few examples such as vertebrate and invertebrate limbs. Drosophila Malpighian/renal tubules (MpTs) are simple epithelial tubules, with a defined P-D axis. How this axis is patterned is not known, and provides an ideal context to understand patterning mechanisms of a secondary axis. Furthermore, epithelial tubules are widespread, and their patterning is not well understood. Here, we describe the mechanism that establishes distal tubule and show this is a radically different mechanism to that patterning the proximal MpT. The distal domain is patterned in two steps: distal identity is specified in a small group of cells very early in MpT development through Wingless/Wnt signalling. Subsequently, this population is expanded by proliferation to generate the distal MpT domain. This mechanism enables distal identity to be established in the tubule in a domain of cells much greater than the effective range of Wingless.
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