Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.

Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.
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DOI:
10.1126/science.1169123
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发表时间:
2009-02-06
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Presgraves DC
Presgraves DC
中科院分区:
其他
文献类型:
--
作者:
Tang S;Presgraves DC

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物种形成通常涉及不相容基因相互作用的进化,这些相互作用导致种群间杂交的不育或致死。这些所谓的杂种不亲和性发生在两个或多个功能不同的基因座之间。我们发现拟果蝇的Nup160基因与D.黑腹果蝇X染色体,导致杂种致死。NUP160编码核孔复合物蛋白,并显示出适应性进化的证据。此外,Nup160编码的蛋白质直接与另一个杂交致死基因Nup96相互作用,表明至少有两个致命的杂交不相容基因已经进化为果蝇核孔复合体相互作用组分之间的分歧共同进化的副产品。
Speciation often involves the evolution of incompatible gene interactions that cause sterility or lethality in hybrids between populations. These so-called hybrid incompatibilities occur between two or more functionally divergent loci. We show that the Nup160 gene of the fruitfly Drosophila simulans is incompatible with a factor(s) on the D. melanogaster X chromosome, causing hybrid lethality. Nup160 encodes a nuclear pore complex protein and shows evidence of adaptive evolution. Furthermore, the protein encoded by Nup160 interacts directly with that of another hybrid lethality gene, Nup96, indicating that at least two lethal hybrid incompatibility genes have evolved as by-products of divergent coevolution among interacting components of the Drosophila nuclear pore complex.
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