Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.
Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.
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DOI:
10.1126/science.1169123
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发表时间:
2009-02-06
期刊:
影响因子:
--
通讯作者:
Presgraves DC
中科院分区:
文献类型:
--
作者:
Tang S;Presgraves DC
Speciation often involves the evolution of incompatible gene interactions that cause sterility or lethality in hybrids between populations. These so-called hybrid incompatibilities occur between two or more functionally divergent loci. We show that the Nup160 gene of the fruitfly Drosophila simulans is incompatible with a factor(s) on the D. melanogaster X chromosome, causing hybrid lethality. Nup160 encodes a nuclear pore complex protein and shows evidence of adaptive evolution. Furthermore, the protein encoded by Nup160 interacts directly with that of another hybrid lethality gene, Nup96, indicating that at least two lethal hybrid incompatibility genes have evolved as by-products of divergent coevolution among interacting components of the Drosophila nuclear pore complex.
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