Anti‐endothelial cell antibodies in insulin‐dependent diabetes mellitus
Anti‐endothelial cell antibodies in insulin‐dependent diabetes mellitus
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胰岛素依赖型糖尿病中的抗内皮细胞抗体
DOI：
10.1111/j.1365-2249.1992.tb06463.x
复制
发表时间：
1992
影响因子：
4.6
通讯作者：
J. Mäenpää
中科院分区：
文献类型：
--
作者：
A. Wangel;S. Kontiainen;T. Scheinin;A. Schlenzka;D. Wangel;J. Mäenpää
通过使用人脐带静脉内皮细胞的酶免疫测定法，在136例胰岛素依赖型糖尿病年轻患者中研究了抗内皮细胞IgG类抗体（AECA）的患病率。根据诊断和研究之间的时间将患者分为四组，并将其结果与对照儿童和献血员进行比较。AECA随着糖尿病病程的延长而逐渐增加，在诊断后2周内检测的糖尿病患者中为4%，在平均病程11-2年后达到34%。它们在神经病变、视网膜病变或肾病患者中并不比没有这些并发症的患者更常见，但与共存的甲状腺疾病和伊加缺乏症相关。结果表明，在胰岛素依赖型糖尿病中，AECA与共存的自身免疫性疾病相关，但与糖尿病微血管疾病无关。
The prevalence of IgG class antibodies to endothelial cells (AECA) was studied in 136 young patients with insulin‐dependent diabetes mellitus by an enzyme immunoassay using human umbilical cord vein endothelial cells. The patients were divided into four groups according to the time between diagnosis and study and their results were compared with those in control children and blood donors. AECA became progressively more frequent with the duration of diabetes, being 4% in diabetics tested within 2 weeks of diagnosis and reaching 34% after an average disease duration of 11–2 years. They were not more common in patients with neuropathy, retinopathy or nephropathy than in patients without these complications, but were associated with co‐existing thyroid disease and IgA deficiency. The results suggest that in insulin‐dependent diabetes mellitus AECA are associated with co‐existing autoimmune disorders but not with diabetic microvascular disease.
系统性血管炎患者血管内皮细胞特异性抗原自身抗体的鉴定。
DOI：
10.1016/s0002-9343(89)80486-3
发表时间：
1989
期刊：
The American journal of medicine
影响因子：
--
作者：
Brasile,L;Kremer,JM;Clarke,JL;Cerilli,J
通讯作者：
Cerilli,J
I 型糖尿病中携带 Ia 抗原的循环 T 细胞增加。
DOI：
10.1056/nejm198204013061305
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jackson,RA;Morris,MA;Haynes,BF;Eisenbarth,GS
通讯作者：
Eisenbarth,GS