Emergence of tuning to natural stimulus statistics along the central auditory pathway.
Emergence of tuning to natural stimulus statistics along the central auditory pathway.
复制标题
DOI：
10.1371/journal.pone.0022584
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Schnupp JW
中科院分区：
文献类型：
--
作者：
Garcia-Lazaro JA;Ahmed B;Schnupp JW
我们之前的研究表明，麻醉雪貂（氯胺酮/美托咪定）初级听觉皮层（A1）的神经元对统计数据遵循“自然”1/f动态的动态刺激的反应比表现出比1/f更快（1/f 0.5）或更慢（1/f 2）的音调和振幅调制的刺激更强烈和可靠。为了研究这种1/f调制调谐在中央听觉通路的何处产生，我们现在表征了下丘中央核（ICC）和丘脑中膝部核腹侧区（MGV）神经元对γ在0.5和2.8之间变化的1/f γ分布刺激的反应。我们发现，虽然从ICC记录的绝大多数神经元对最快速变化（1/f 0.5分布）的刺激表现出强烈的偏好，但MGV神经元的反应并没有对任何特定的γ指数表现出明显或系统的偏好。只有在A1中，大多数神经元对γ值接近1的刺激有更高的放电率反应。这些结果表明，1/f调谐出现在上升听觉通路的前脑水平。
We have previously shown that neurons in primary auditory cortex (A1) of anaesthetized (ketamine/medetomidine) ferrets respond more strongly and reliably to dynamic stimuli whose statistics follow “natural” 1/f dynamics than to stimuli exhibiting pitch and amplitude modulations that are faster (1/f 0.5) or slower (1/f 2) than 1/f. To investigate where along the central auditory pathway this 1/f-modulation tuning arises, we have now characterized responses of neurons in the central nucleus of the inferior colliculus (ICC) and the ventral division of the mediate geniculate nucleus of the thalamus (MGV) to 1/f γ distributed stimuli with γ varying between 0.5 and 2.8. We found that, while the great majority of neurons recorded from the ICC showed a strong preference for the most rapidly varying (1/f 0.5 distributed) stimuli, responses from MGV neurons did not exhibit marked or systematic preferences for any particular γ exponent. Only in A1 did a majority of neurons respond with higher firing rates to stimuli in which γ takes values near 1. These results indicate that 1/f tuning emerges at forebrain levels of the ascending auditory pathway.
登录
查看更多内容
影响因子：
64.8
作者：
VOSS, RF;CLARKE, J
通讯作者：
CLARKE, J
影响因子：
2.5
作者：
Miller, LM;Escabí, MA;Schreiner, CE
通讯作者：
Schreiner, CE
影响因子：
2.5
作者：
Fuzessery, Zoltan M.;Richardson, Marlin D.;Coburn, Michael S.
通讯作者：
Coburn, Michael S.
影响因子：
9.2
作者：
Garcia-Lazaro, JA;Ahmed, B;Schnupp, JWH
通讯作者：
Schnupp, JWH
影响因子：
2.4
作者：
VOSS, RF;CLARKE, J
通讯作者：
CLARKE, J