MicroRNAs in brain development and function: a matter of flexibility and stability.
MicroRNAs in brain development and function: a matter of flexibility and stability.
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DOI：
10.3389/fnmol.2014.00005
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发表时间：
2014
影响因子：
4.8
通讯作者：
Béclin C
中科院分区：
文献类型：
--
作者：
Follert P;Cremer H;Béclin C
基因表达的微调是细胞和器官发育和功能的基本要求。这种要求在神经系统中特别明显，其中最初常见的干细胞群体以时间和数量上完美协调的方式产生数千种不同的神经元和神经胶质细胞类型。此外，在它们产生之后，年轻的神经元必须通过建立功能性突触与预先确定的目标神经元连接，无论是在它们的直接环境中还是在远处。最后，大脑功能不仅依赖于静态电路，还依赖于突触水平的可塑性变化，从而实现学习和记忆。显然，这些进程同时需要灵活性和稳定性。这两种截然不同的特征只能通过复杂的分子网络、叠加的控制水平和调节机制之间的紧密相互作用来实现。microRNA与其靶mRNA之间的相互作用满足了这些要求。在这里，我们回顾了最近的文献涉及的microRNA参与大脑发育和连接的多个方面。
Fine-tuning of gene expression is a fundamental requirement for development and function of cells and organs. This requirement is particularly obvious in the nervous system where originally common stem cell populations generate thousands of different neuronal and glial cell types in a temporally and quantitatively perfectly orchestrated manner. Moreover, after their generation, young neurons have to connect with pre-determined target neurons through the establishment of functional synapses, either in their immediate environment or at distance. Lastly, brain function depends not only on static circuitries, but on plastic changes at the synaptic level allowing both, learning and memory. It appears evident that these processes necessitate flexibility and stability at the same time. These two contrasting features can only be achieved by complex molecular networks, superposed levels of control and tight interactions between regulatory mechanisms. Interactions between microRNAs and their target mRNAs fulfill these requirements. Here we review recent literature dealing with the involvement of microRNAs in multiple aspects of brain development and connectivity.
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影响因子：
5.3
作者：
de Chevigny A;Core N;Follert P;Wild S;Bosio A;Yoshikawa K;Cremer H;Beclin C
通讯作者：
Beclin C
DOI：
10.1073/pnas.96.17.9873
发表时间：
1999-08-17
影响因子：
11.1
作者：
Andrés, ME;Burger, C;Mandel, G
通讯作者：
Mandel, G
DOI：
10.1073/pnas.1017576108
发表时间：
2011-07-12
影响因子：
11.1
作者：
Cohen, Jonathan E.;Lee, Philip R.;Fields, R. Douglas
通讯作者：
Fields, R. Douglas
影响因子：
16.2
作者：
Bowers, M. Scott;Chen, Billy T.;Bonci, Antonello
通讯作者：
Bonci, Antonello
影响因子：
3.5
作者：
Christensen M;Larsen LA;Kauppinen S;Schratt G
通讯作者：
Schratt G