Acute Kidney Injury and Pediatric Bone Health.

Acute Kidney Injury and Pediatric Bone Health.
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DOI:
10.3389/fped.2020.635628
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发表时间:
2020
影响因子:
2.6
通讯作者:
Glenn DA
Glenn DA
中科院分区:
医学3区
文献类型:
--
作者:
Hegde A;Denburg MR;Glenn DA

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急性肾损伤(阿基)与多种身体系统的有害影响有关。虽然阿基通常伴随着矿物质代谢的失调,包括钙、磷酸盐、维生素D、甲状旁腺激素、成纤维细胞生长因子23和klotho的改变,但其对儿童和青少年骨骼系统的直接影响在很大程度上仍未被探索。在这篇综述中,讨论了阿基中矿物质代谢失调的病理生理学及其对骨骼健康的潜在影响,包括阿基与骨折风险相关的数据。
Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism—including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho—its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.
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