Plasma FGF23 levels increase rapidly after acute kidney injury.
Plasma FGF23 levels increase rapidly after acute kidney injury.
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DOI：
10.1038/ki.2013.150
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发表时间：
2013-10
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
--
作者：
新出现的证据表明，成纤维细胞生长因子23（FGF23）水平在急性肾损伤（阿基）患者中升高。为了确定这种增加多早发生，我们使用了鼠叶酸肾病模型，发现血浆FGF 23水平在阿基1小时后已经从基线显著增加，在24小时增加了18倍。当在骨细胞特异性甲状旁腺激素受体消融或甲状旁腺激素或维生素D受体整体缺失的小鼠中诱导阿基时，发现FGF 23水平类似升高，表明FGF 23的增加不依赖于甲状旁腺激素和维生素D信号传导。此外，在诱导阿基之前维持正常或磷酸盐耗尽饮食的野生型小鼠中，FGF23水平增加至类似程度，表明显著的FGF23升高至少部分地不依赖于饮食磷酸盐。在阿基中，FGF 23的骨产生显著增加。静脉内施用的重组FGF 23的半衰期仅适度增加。与小鼠数据一致，发生阿基的患者在心脏手术后24小时内血浆FGF 23水平升高了15.9倍。这些水平显著高于术后未发生阿基的患者。因此，在啮齿动物和人类中，阿基期间循环FGF 23水平迅速升高。在小鼠中，这种增加不依赖于已建立的FGF 23分泌调节剂。
Emerging evidence suggests that fibroblast growth factor 23 (FGF23) levels are elevated in patients with acute kidney injury (AKI). In order to determine how early this increase occurs we used a murine folic acid nephropathy model and found that plasma FGF23 levels increased significantly from baseline already after 1 hour of AKI, with an 18-fold increase at 24 hours. Similar elevations of FGF23 levels were found when AKI was induced in mice with osteocyte-specific parathyroid hormone receptor ablation or the global deletion of parathyroid hormone or vitamin D receptor, indicating that the increase in FGF23 was independent of parathyroid hormone and vitamin D signaling. Furthermore, FGF23 levels increased to a similar extent in wild-type mice maintained on normal or phosphate-depleted diets prior to induction of AKI, indicating that the marked FGF23 elevation is at least partially independent of dietary phosphate. Bone production of FGF23 was significantly increased in AKI. The half-life of intravenously administered recombinant FGF23 was only modestly increased. Consistent with the mouse data, plasma FGF23 levels rose 15.9-fold by 24 hours following cardiac surgery in patients who developed AKI. The levels were significantly higher than in those without postoperative AKI. Thus, circulating FGF23 levels rise rapidly during AKI in rodents and humans. In mice this increase is independent of established modulators of FGF23 secretion.
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影响因子：
3.3
作者：
Ito, Nobuaki;Fukumoto, Seiji;Fujita, Toshiro
通讯作者：
Fujita, Toshiro
影响因子：
6.2
作者：
Burnett-Bowie, Sherri-Ann M.;Henao, Maria P.;Leder, Benjamin Z.
通讯作者：
Leder, Benjamin Z.
DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
19.6
作者：
Bucaloiu, Ion D.;Kirchner, H. Lester;Perkins, Robert M.
通讯作者：
Perkins, Robert M.
影响因子：
13.6
作者：
Ishani, Areef;Xue, Jay L.;Collins, Allan J.
通讯作者：
Collins, Allan J.