Scatter-plate microscope for lensless microscopy with diffraction limited resolution.
Scatter-plate microscope for lensless microscopy with diffraction limited resolution.
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DOI：
10.1038/s41598-017-10767-3
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发表时间：
2017-09-06
影响因子：
4.6
通讯作者：
Osten W
中科院分区：
文献类型：
--
作者：
Singh AK;Pedrini G;Takeda M;Osten W
散射介质一直被视为成像的障碍。为了克服这一障碍，人们提出了各种方法，从全息照相术到相位补偿以及相关技术。另一方面，我们对传播媒介的作用有不同的理解。在这篇文章中，我们提出并演示了一种利用随机介质的扩散特性来成像具有衍射极限分辨率的微结构的散射板显微镜。散斑图案的无处不在的特性允许将散射介质用作具有可变焦距和大工作距离的超薄无透镜显微镜物镜。该方法提供了一种轻便、灵活且具有成本效益的成像设备，作为传统显微镜物镜的替代。原则上，该技术也适用于紫外线和X射线显微镜中的无透镜成像。用可见光演示了USAF分辨率测试靶和不同数值孔径(NA)和放大倍数的生物样品的显微成像。
Scattering media have always been looked upon as an obstacle in imaging. Various methods, ranging from holography to phase compensation as well as to correlation techniques, have been proposed to cope with this obstacle. We, on the other hand, have a different understanding about the role of the diffusing media. In this paper we propose and demonstrate a ‘scatter-plate microscope’ that utilizes the diffusing property of the random medium for imaging micro structures with diffraction-limited resolution. The ubiquitous property of the speckle patterns permits to exploit the scattering medium as an ultra-thin lensless microscope objective with a variable focal length and a large working distance. The method provides a light, flexible and cost effective imaging device as an alternative to conventional microscope objectives. In principle, the technique is also applicable to lensless imaging in UV and X-ray microscopy. Experiments were performed with visible light to demonstrate the microscopic imaging of USAF resolution test target and a biological sample with varying numerical aperture (NA) and magnifications.
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