Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review.
Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review.
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DOI：
10.1155/2018/6936727
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发表时间：
2018
影响因子：
4.1
通讯作者：
Puxeddu R
中科院分区：
文献类型：
--
作者：
Puxeddu I;Capecchi R;Carta F;Tavoni AG;Migliorini P;Puxeddu R
IgG4相关疾病（IgG4-RD）是一种罕见的纤维炎性疾病，几乎可以影响任何器官，其特征是肿胀的病变，通常是嗜酸性粒细胞增多和血清IgG4浓度升高。IgG4-RD的诊断是一项具有挑战性的任务：事实上，单个或多个器官可能受到影响，临床，血清学和组织学结果可能是异质性的。在IgG4-RD中，在27%至53%的患者中观察到唾液腺受累。几种器官特异性疾病，现在被认为是IgG 4相关性涎腺炎（IgG 4-RS）的不同表现，过去被视为单个疾病实体。唾液腺的研究有时可能是复杂的，因为可能影响它们的病理条件的数量，通常具有重叠的临床图像。在唾液腺肿胀的情况下，通常需要整合不同的成像技术，即使活检仍然是IgG4-RS明确诊断的金标准。因此，在这篇综述中，我们讨论了新的见解IgG4-RD的发病机制，侧重于其临床方面和工具，目前可用于正确的鉴别诊断时，唾液腺参与。
IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved.
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影响因子：
13.5
作者：
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通讯作者：
de Vries, Niek
影响因子：
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作者：
Mavragani, Clio P.;Fragoulis, George E.;Moutsopoulos, Haralampos M.
通讯作者：
Moutsopoulos, Haralampos M.
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影响因子：
4.9
作者：
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通讯作者：
Lipsky PE
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
27.4
作者：
Della-Torre E;Feeney E;Deshpande V;Mattoo H;Mahajan V;Kulikova M;Wallace ZS;Carruthers M;Chung RT;Pillai S;Stone JH
通讯作者：
Stone JH