Computational approaches to RNA structure prediction, analysis, and design.
Computational approaches to RNA structure prediction, analysis, and design.
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DOI:
10.1016/j.sbi.2011.03.015
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发表时间:
2011-06
影响因子:
6.8
通讯作者:
Schlick, Tamar
中科院分区:
文献类型:
--
作者:
Laing, Christian;Schlick, Tamar
RNA molecules are important cellular components involved in many fundamental biological processes. Understanding the mechanisms behind their functions requires RNA tertiary structure knowledge. While modeling approaches for the study of RNA structures and dynamics lag behind efforts in protein folding, much progress has been achieved in the past two years. Here, we review recent advances in RNA folding algorithms, RNA tertiary motif discovery, applications of graph theory approaches to RNA structure and function, and in silico generation of RNA sequence pools for aptamer design. Advances within each area can be combined to impact many problems in RNA structure and function.
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