Glycobiology in osteoclast differentiation and function.
Glycobiology in osteoclast differentiation and function.
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DOI：
10.1038/s41413-023-00293-6
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发表时间：
2023-10-26
期刊：
影响因子：
12.7
通讯作者：
Dai, Hui
中科院分区：
文献类型：
--
作者：
Yang, Shufa;He, Ziyi;Wu, Tuo;Wang, Shunlei;Dai, Hui
聚糖，无论是单独的还是与聚糖结合蛋白复合的，都是在生理和病理条件下通过介导蛋白质稳定性或受体二聚化来调节细胞生物学的重要结构。某些聚糖是凝集素的配体，凝集素是碳水化合物特异性受体。骨骼是一种复杂的组织，为肌肉和关节提供机械支撑，哺乳动物中骨量的调节是由成骨细胞（称为成骨细胞）和骨吸收细胞（称为破骨细胞）之间复杂的相互作用控制的。当骨吸收明显超过骨形成时，就会发生骨侵蚀。破骨细胞可能在癌症期间被激活，导致一系列症状，包括骨痛、骨折和脊髓受压。我们对蛋白质糖基化在破骨细胞生成所涉及的细胞和组织中的作用的理解表明，基于糖基化的治疗可用于疾病的治疗。本综述的目的是阐明骨吸收过程并研究糖基化介导的信号通路及其在破骨细胞生物学中的作用。此外，我们的目的是概述从这些方法中吸取的经验教训如何为未来以糖生物学为重点的治疗铺平道路。
Glycans, either alone or in complex with glycan-binding proteins, are essential structures that can regulate cell biology by mediating protein stability or receptor dimerization under physiological and pathological conditions. Certain glycans are ligands for lectins, which are carbohydrate-specific receptors. Bone is a complex tissue that provides mechanical support for muscles and joints, and the regulation of bone mass in mammals is governed by complex interplay between bone-forming cells, called osteoblasts, and bone-resorbing cells, called osteoclasts. Bone erosion occurs when bone resorption notably exceeds bone formation. Osteoclasts may be activated during cancer, leading to a range of symptoms, including bone pain, fracture, and spinal cord compression. Our understanding of the role of protein glycosylation in cells and tissues involved in osteoclastogenesis suggests that glycosylation-based treatments can be used in the management of diseases. The aims of this review are to clarify the process of bone resorption and investigate the signaling pathways mediated by glycosylation and their roles in osteoclast biology. Moreover, we aim to outline how the lessons learned about these approaches are paving the way for future glycobiology-focused therapeutics.
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影响因子：
3.7
作者：
Sehic E;Westerlund A;Lagerquist MK;Lerner UH;Carlsten H;Henning P;Engdahl C
通讯作者：
Engdahl C
影响因子：
3.3
作者：
Cylwik B;Gruszewska E;Gindzienska-Sieskiewicz E;Kowal-Bielecka O;Chrostek L
通讯作者：
Chrostek L
影响因子：
4.3
作者：
Angata, Takashi;Tabuchi, Yukako;Nakamura, Mitsuru
通讯作者：
Nakamura, Mitsuru
影响因子：
6.2
作者：
Cui, Shun;Xiong, Fei;Hong, Yan;Jung, Ji-Ung;Li, Xing-Sheng;Liu, Jian-Zhong;Yan, Riqiang;Mei, Lin;Feng, Xu;Xiong, Wen-Cheng
通讯作者：
Xiong, Wen-Cheng
影响因子：
--
作者：
BALAZS, EA;WATSON, D;ROSEMAN, S
通讯作者：
ROSEMAN, S