Two kinds of urinary continence reflexes during abrupt elevation of intravesical pressure in rats.
Two kinds of urinary continence reflexes during abrupt elevation of intravesical pressure in rats.
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DOI：
10.1111/j.1757-5672.2009.00026.x
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发表时间：
2009-09-01
期刊：
影响因子：
--
通讯作者：
Yoshimura N
中科院分区：
文献类型：
--
作者：
Kamo I;Kaiho Y;Miyazato M;Torimoto K;Yoshimura N
尿道闭合机制在潜行期间突然升高，在偷偷摸摸的过程中观察到中间尿道闭合反应，并且在打开腹部后仍保留了尿道的尿道。外部尿道括约肌和骨盆底肌肉，而双侧骨盆神经和次生神经的双侧转移没有效果。在偷偷摸摸的过程中，尿道孔的流体泄漏在PVE中渗出120秒。通过双侧切割骨盆神经，完全消除了反应，并在双侧神经转导后部分降低，神经向骨盆底肌肉或下腹神经。当骨盆神经或躯体神经切割双侧时，尿道孔降低了，而双侧次生神经则显示出较小的结果表明在PVE的突然升高期间，至少有两种尿道反射在雪橇中观察到的一个反射是预先编程的，以便关闭尿道的尿道，无论是自动的，无论是叶片的传入活动而言在暂时的压力事件中尽管在相对较长的时期（如被动PVE）抬高120秒的情况下，肌肉和平滑肌肉都参与预防压力尿失禁。
Urethral closure mechanisms during abrupt elevation of intravesical pressure (Pves) were investigated. During sneezing, the middle urethral closing response was observed and it still remained after opening the abdomen. The middle urethral response was almost completely abolished after bilateral transection of somatic nerves innervating the external urethral sphincter and the pelvic floor muscles, while bilateral transection of both pelvic nerves and hypogastric nerves had no effects. Somatic nerve transection resulted in fluid leakage from the urethral orifice during sneezing. Passive increments of Pves for 120 seconds by elevating a saline reservoir connected to the bladder also induced the middle urethral closing response in rats with spinal cord transection at T8–T9. The response was totally abolished by cutting pelvic nerves bilaterally, and partially reduced after bilateral transection of pudendal nerves, nerves to pelvic floor muscles or hypogastric nerves. Electrical stimulation of abdominal muscles (ESAM) for 1 second elevated Pves in a stimulus-dependent manner in the spinal cord-transected rats, and the Pves rise was almost lost when the abdomen was opened. The Pves inducing fluid leakage from the urethral orifice was lowered in rats when pelvic nerves or somatic nerves were cut bilaterally, while transection of bilateral hypogastric nerves showed smaller effects. These results indicate that at least two kinds of urinary continence reflexes close the middle urethra during abrupt elevation of Pves; one reflex observed during sneeze is preprogrammed so as to close the urethra automatically irrespective of bladder afferent activity, and the other reflex is triggered by bladder afferent excitation. During momentary stress events such as sneezing (<0.15 seconds) and ESAM (1 second), the striated muscles mainly contribute to the urethral closure, while during events for a relatively long period like passive Pves elevation for 120 seconds, both striated and smooth muscles are involved in the prevention of stress urinary incontinence.
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影响因子：
1.8
作者：
Conway, DA;Kamo, I;Cannon, TW
通讯作者：
Cannon, TW
DOI：
10.1152/ajprenal.00330.2005
发表时间：
2006-05-01
影响因子：
4.2
作者：
Jankowski, RJ;Prantil, RL;Vorp, DA
通讯作者：
Vorp, DA
DOI：
10.1152/ajprenal.00038.2004
发表时间：
2004-09-01
影响因子：
4.2
作者：
Kamo, I;Cannon, TW;Yoshimura, N
通讯作者：
Yoshimura, N
DOI：
10.1111/j.1464-410x.1990.tb14960.x
发表时间：
1990-10-01
期刊：
BRITISH JOURNAL OF UROLOGY
影响因子：
--
作者：
THIND, P;LOSE, G;COLSTRUP, H
通讯作者：
COLSTRUP, H
DOI：
10.1152/ajprenal.00466.2006
发表时间：
2007-09-01
影响因子：
4.2
作者：
Kamo, Izumi;Hashimoto, Tadatoshi
通讯作者：
Hashimoto, Tadatoshi