Variable dendritic integration in hippocampal CA3 pyramidal neurons.
Variable dendritic integration in hippocampal CA3 pyramidal neurons.
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DOI：
10.1016/j.neuron.2013.10.033
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发表时间：
2013-12-18
期刊：
影响因子：
16.2
通讯作者：
Magee JC
中科院分区：
文献类型：
--
作者：
Makara JK;Magee JC
海马CA 3区对于图案完成和尖波涟漪的产生至关重要。在这些操作过程中，协调激活CA3锥体神经元的集合产生时空结构的输入模式，到达递归连接的CA3神经元的树突上。为了了解这些输入模式如何转化为特定的输出模式，我们使用双光子成像和谷氨酸释放来表征CA3锥体细胞中的树突整合。我们发现，薄树突的CA3锥体神经元整合同步突触输入在一个高度超线性的方式。扩增主要由NMDA受体激活介导，并存在于一个相对广泛的时空输入模式。衰减的电压响应，时间总和，和动作电位输出的规定在一个区室化的方式主要是由G蛋白激活的内向整流K+电流。我们的研究结果表明，可塑性树突整合机制可能支持海马电路锥体神经元的整体行为。CA3锥体神经元中的主动非线性树突整合NMDAR介导同步突触输入的放大K+通道对树突整合和体细胞输出的区室化控制Makara和Magee证明了海马CA3锥体神经元的细树突中的多个协同作用突触输入的NMDA受体介导的超线性树突整合，并揭示了G蛋白对这些NMDA尖峰的有力调节。激活内向整流钾通道。
The hippocampal CA3 region is essential for pattern completion and generation of sharp-wave ripples. During these operations, coordinated activation of ensembles of CA3 pyramidal neurons produces spatiotemporally structured input patterns arriving onto dendrites of recurrently connected CA3 neurons. To understand how such input patterns are translated into specific output patterns, we characterized dendritic integration in CA3 pyramidal cells using two-photon imaging and glutamate uncaging. We found that thin dendrites of CA3 pyramidal neurons integrate synchronous synaptic input in a highly supralinear fashion. The amplification was primarily mediated by NMDA receptor activation and was present over a relatively broad range of spatiotemporal input patterns. The decay of voltage responses, temporal summation, and action potential output was regulated in a compartmentalized fashion mainly by a G-protein-activated inwardly rectifying K+ current. Our results suggest that plastic dendritic integrative mechanisms may support ensemble behavior in pyramidal neurons of the hippocampal circuitry. Active nonlinear dendritic integration in CA3 pyramidal neurons NMDARs mediate amplification of synchronous synaptic inputs Compartmentalized control of dendritic integration and somatic output by K+ channels Makara and Magee demonstrate NMDA receptor-mediated supralinear dendritic integration of multiple coactive synaptic inputs in thin dendrites of hippocampal CA3 pyramidal neurons and reveal a powerful regulation of these NMDA spikes by G-protein-activated inwardly rectifying K+ channels.
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DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
2.9
作者：
Jin, WL;Lu, Z
通讯作者：
Lu, Z
影响因子：
64.8
作者：
Losonczy, Attila;Makara, Judit K.;Magee, Jeffrey C.
通讯作者：
Magee, Jeffrey C.
影响因子：
4.2
作者：
Antic SD;Zhou WL;Moore AR;Short SM;Ikonomu KD
通讯作者：
Ikonomu KD
影响因子：
5.3
作者：
Legenstein, Robert;Maass, Wolfgang
通讯作者：
Maass, Wolfgang