The decade of the dendritic NMDA spike.
The decade of the dendritic NMDA spike.
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DOI：
10.1002/jnr.22444
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发表时间：
2010-11-01
影响因子：
4.2
通讯作者：
Ikonomu KD
中科院分区：
文献类型：
--
作者：
Antic SD;Zhou WL;Moore AR;Short SM;Ikonomu KD
在皮质细胞生理学领域，人们投入了大量精力来理解锥体神经元的粗顶树突和发生在顶干中的再生钠和钙尖峰。在这里，我们专注于薄树突的锥体细胞（基底，斜，簇树突），我们讨论了一个相对新颖的形式的电信号（“NMDA穗”），这是特定于这些分支。基底、斜向和顶端簇状树突接受高密度的突触接触。同步激活10-50个相邻的突触能触发局部树突再生电位，NMDA尖峰/平台，其特征在于显著的局部振幅（40-50 mV）和异常的持续时间（高达几百毫秒）。NMDA平台电位，当它在顶端簇树突中启动时，能够将该簇的良好部分维持在持续去极化状态。然而，如果NMDA主导的平台电位起源于基底树突的近端部分，它们会定期使神经元细胞体进入持续的去极化状态，这类似于皮质向上状态。在每个树突起始位点（基底、斜向和簇），NMDA尖峰为主动突触输入的因果相互作用创造有利条件，包括信息的空间或时间结合，以及短期和长期突触修饰的过程（例如，长时程增强或长时程抑制）。由于其强大的振幅和持续时间，局部树突状NMDA尖峰构成了多位点独立亚基计算的细胞基质，丰富了皮质锥体细胞的计算能力和库。我们认为，NMDA棘波可能在清醒动物（时空结合、工作记忆）和慢波睡眠期间（神经元兴奋状态、记忆巩固）的皮质信息处理中发挥重要作用。
In the field of cortical cellular physiology, much effort has been invested in understanding thick apical dendrites of pyramidal neurons and the regenerative sodium and calcium spikes that take place in the apical trunk. Here we focus on thin dendrites of pyramidal cells (basal, oblique, and tuft dendrites), and we discuss one relatively novel form of an electrical signal (“NMDA spike”) that is specific for these branches. Basal, oblique, and apical tuft dendrites receive a high density of glutamatergic synaptic contacts. Synchronous activation of 10–50 neighboring glutamatergic synapses triggers a local dendritic regenerative potential, NMDA spike/plateau, which is characterized by significant local amplitude (40–50 mV) and an extraordinary duration (up to several hundred milliseconds). The NMDA plateau potential, when it is initiated in an apical tuft dendrite, is able to maintain a good portion of that tuft in a sustained depolarized state. However, if NMDA-dominated plateau potentials originate in proximal segments of basal dendrites, they regularly bring the neuronal cell body into a sustained depolarized state, which resembles a cortical up state. At each dendritic initiation site (basal, oblique, and tuft) an NMDA spike creates favorable conditions for causal interactions of active synaptic inputs, including the spatial or temporal binding of information, as well as processes of short-term and long-term synaptic modifications (e.g., long-term potentiation or long-term depression). Because of their strong amplitudes and durations, local dendritic NMDA spikes make up the cellular substrate for multisite independent subunit computations that enrich the computational power and repertoire of cortical pyramidal cells. We propose that NMDA spikes are likely to play significant roles in cortical information processing in awake animals (spatiotemporal binding, working memory) and during slow-wave sleep (neuronal up states, consolidation of memories).
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DOI：
10.1023/a:1024134312173
发表时间：
2002-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Benavides-Piccione, R;Ballesteros-Yáñez, I;Yuste, R
通讯作者：
Yuste, R
影响因子：
25
作者：
Archie, KA;Mel, BW
通讯作者：
Mel, BW
影响因子：
16.2
作者：
Haider, Bilal;McCormick, David A.
通讯作者：
McCormick, David A.
影响因子：
5.3
作者：
Gordon, Urit;Polsky, Alon;Schiller, Jackie
通讯作者：
Schiller, Jackie
影响因子：
5.5
作者：
Canepari, Marco;Djurisic, Maja;Zecevic, Dejan
通讯作者：
Zecevic, Dejan