β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.
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DOI：
10.1038/nn.4035
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发表时间：
2015-07
影响因子：
25
通讯作者：
Walker, Matthew P.
中科院分区：
文献类型：
--
作者：
Mander, Bryce A.;Marks, Shawn M.;Vogel, Jacob W.;Rao, Vikram;Lu, Brandon;Saletin, Jared M.;Ancoli-Israel, Sonia;Jagust, William J.;Walker, Matthew P.
独立证据表明，β-淀粉样蛋白病理与老年人的非快速眼动睡眠障碍和记忆障碍有关。然而，β-淀粉样变性对海马区依赖记忆的影响是否在一定程度上是由NREM慢波活动(SWA)和相关的夜间记忆巩固的损害驱动的，目前尚不清楚。在这里，我们表明，内侧前额叶皮质(MPFC)内的β-淀粉样蛋白负荷与NREM SWA代损伤的严重程度显著相关。此外，NREM SWA生成的减少进一步与夜间记忆巩固受损和贫穷的海马区-新皮质记忆转换有关。此外，结构方程模型显示，mPFCβ-淀粉样蛋白病理与受损的海马区依赖的记忆巩固之间的联系不是直接的，而是统计上依赖于NREM SWA减少的中间因素。通过将β-淀粉样蛋白病理与受损的NREM SWA联系起来，这些数据暗示睡眠障碍是一种新的机制途径，β-淀粉样蛋白病理可能通过这种途径导致老年人海马体依赖的认知能力下降。
Independent evidence associates β-amyloid pathology with both NREM sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated overnight memory consolidation is unknown. Here, we show that β-amyloid burden within medial prefrontal cortex (mPFC) is significantly correlated with the severity of impairment in NREM SWA generation. Moreover, reduced NREM SWA generation was further associated with impaired overnight memory consolidation and impoverished hippocampal-neocortical memory transformation. Furthermore, structural equation models revealed that the association between mPFC β-amyloid pathology and impaired hippocampus-dependent memory consolidation is not direct, but instead, statistically depends on the intermediary factor of diminished NREM SWA. By linking β-amyloid pathology with impaired NREM SWA, these data implicate sleep disruption as a novel mechanistic pathway through which β-amyloid pathology may contribute to hippocampus-dependent cognitive decline in the elderly.
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DOI：
10.1093/cercor/bhr172
发表时间：
2012-05
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Hedden T;Van Dijk KR;Shire EH;Sperling RA;Johnson KA;Buckner RL
通讯作者：
Buckner RL
DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
3.4
作者：
Carrier, Julie;Viens, Isabelle;Filipini, Daniel
通讯作者：
Filipini, Daniel
DOI：
10.1523/jneurosci.2462-12.2012
发表时间：
2012-11-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hedden T;Mormino EC;Amariglio RE;Younger AP;Schultz AP;Becker JA;Buckner RL;Johnson KA;Sperling RA;Rentz DM
通讯作者：
Rentz DM
影响因子：
3
作者：
BOZDOGAN, H
通讯作者：
BOZDOGAN, H