Failure to modulate attentional control in advanced aging linked to white matter pathology.
Failure to modulate attentional control in advanced aging linked to white matter pathology.
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DOI：
10.1093/cercor/bhr172
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Buckner RL
中科院分区：
文献类型：
--
作者：
Hedden T;Van Dijk KR;Shire EH;Sperling RA;Johnson KA;Buckner RL
高级衰老与注意力控制能力下降和信息处理灵活性降低有关。在这里，使用功能性磁共振成像任务探索了这些认知效应的起源，该任务系统地改变了转移注意力并抑制跨任务块的不相关信息的要求。以前与注意力控制有关的前额叶和顶叶区域是由任务招募的，尤其是对于最苛刻的任务配置。一部分老年人并没有根据不断变化的任务要求来调节额叶和顶叶区域的活动。没有动态调节活动的老年人表现不佳，并且在执行功能和处理速度的神经心理学测量方面得分更差。检查老年人临床前病理学的 2 种标志物发现，白质高信号 (WMH)，而不是高淀粉样蛋白负荷，与未能调节活动以响应不断变化的任务需求有关。相反，高淀粉样蛋白负荷与默认网络活动的改变相关。这些结果表明，调节额叶和顶叶活动的失败反映了与特定神经病理过程相关的晚期衰老的破坏性过程。
Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant information across task blocks. Prefrontal and parietal regions previously implicated in attentional control were recruited by the task and most so for the most demanding task configurations. A subset of older individuals did not modulate activity in frontal and parietal regions in response to changing task requirements. Older adults who did not dynamically modulate activity underperformed their peers and scored more poorly on neuropsychological measures of executive function and speed of processing. Examining 2 markers of preclinical pathology in older adults revealed that white matter hyperintensities (WMHs), but not high amyloid burden, were associated with failure to modulate activity in response to changing task demands. In contrast, high amyloid burden was associated with alterations in default network activity. These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
11.2
作者：
Dierksen, Gregory A.;Skehan, Maureen E.;Khan, Muhammad A.;Jeng, Jed;Nandigam, R. N. Kaveer;Becker, John A.;Kumar, Ashok;Neal, Krista L.;Betensky, Rebecca A.;Frosch, Matthew P.;Rosand, Jonathan;Johnson, Keith A.;Viswanathan, Anand;Salat, David H.;Greenberg, Steven M.
通讯作者：
Greenberg, Steven M.
影响因子：
3.7
作者：
Colcombe, SJ;Kramer, AF;Scalf, P
通讯作者：
Scalf, P
影响因子：
--
作者：
Burns, JM;Church, JA;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.