Orbitofrontal cortex control of striatum leads economic decision-making.
Orbitofrontal cortex control of striatum leads economic decision-making.
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DOI：
10.1038/s41593-023-01409-1
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发表时间：
2023-09
影响因子：
25
通讯作者：
Deisseroth, Karl
中科院分区：
文献类型：
--
作者：
Gore, Felicity;Hernandez, Melissa;Ramakrishnan, Charu;Crow, Ailey K. K.;Malenka, Robert C. C.;Deisseroth, Karl
动物必须不断地评估环境中的刺激，以决定追求哪些机会，在许多情况下，这些决定可以从根本上从经济学的角度来理解。虽然有几个大脑区域单独参与了这些过程，但在决策过程中与这些区域相关的全脑机制尚不清楚。使用一个适合大鼠的经济决策任务，我们发现，在两个相连的大脑区域，腹外侧眶额皮质（OFC）和背内侧纹状体（DMS）的神经活动，需要经济决策。两个大脑区域的相关神经活动惊人地相似，都是由决策过程的空间特征所主导。然而，在OFC的选择方向的神经编码之前的DMS，这种时间关系是强烈相关的选择准确性。此外，为作出适当的经济决策，需要开展活动，特别是在OFC向DMS的预测方面。这些结果表明，在OFC的选择信息被中继到DMS，导致准确的经济决策。作者表明，选择信息从腹外侧眶额皮层传递到背内侧纹状体，以引导准确的经济决策。
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear. Using an economic decision-making task adapted for rats, we find that neural activity in both of two connected brain regions, the ventrolateral orbitofrontal cortex (OFC) and the dorsomedial striatum (DMS), was required for economic decision-making. Relevant neural activity in both brain regions was strikingly similar, dominated by the spatial features of the decision-making process. However, the neural encoding of choice direction in OFC preceded that of DMS, and this temporal relationship was strongly correlated with choice accuracy. Furthermore, activity specifically in the OFC projection to the DMS was required for appropriate economic decision-making. These results demonstrate that choice information in the OFC is relayed to the DMS to lead accurate economic decision-making. The authors show that choice information is relayed from the ventrolateral orbitofrontal cortex to the dorsomedial striatum to lead accurate economic decision-making.
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影响因子：
64.8
作者：
Ballesta S;Shi W;Conen KE;Padoa-Schioppa C
通讯作者：
Padoa-Schioppa C
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
16.2
作者：
Groman, Stephanie M.;Keistler, Colby;Taylor, Jane R.
通讯作者：
Taylor, Jane R.
影响因子：
3.4
作者：
Chase, E. Alexander;Tait, David S.;Brown, Verity J.
通讯作者：
Brown, Verity J.