Resolution of inflammation in asthma.
Resolution of inflammation in asthma.
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DOI：
10.1016/j.ccm.2012.06.006
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发表时间：
2012-09
影响因子：
5.7
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Levy BD;Vachier I;Serhan CN
健康气道中炎症的消退是一个主动过程，具有专门的介质和细胞机制，用于恢复组织稳态。在这篇文章中，我们将集中在最近发现的天然介质来自必需脂肪酸，包括欧米茄-3脂肪酸，具有抗炎和促进解决行动。这些专门的促消退介质作为特定受体的激动剂。哮喘是一种慢性、不缓解的气道炎症疾病，目前尚无治愈方法。虽然促缓解介质的生物合成发生在哮喘期间，但其产生的缺陷与疾病的严重程度相关，表明哮喘的病理生物学可能是由于气道炎症的缓解受损。
The resolution of inflammation in healthy airways is an active process with specialized mediators and cellular mechanisms that are enlisted to restore tissue homeostasis. In this article, we will focus on recent discoveries of natural mediators derived from essential fatty acids, including omega-3 fatty acids, that have anti-inflammatory and pro-resolving actions. These specialized pro-resolving mediators serve as agonists at specific receptors. Asthma is a disease of chronic, non-resolving inflammation of the airway without known cure. While the biosynthesis of pro-resolving mediators occurs during asthma, defects in their production are associated with disease severity, suggesting that the pathobiology of asthma may result from impaired resolution of airway inflammation.
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影响因子：
5.8
作者：
Bhavsar PK;Levy BD;Hew MJ;Pfeffer MA;Kazani S;Israel E;Chung KF
通讯作者：
Chung KF
影响因子：
30.5
作者：
Aliberti, J;Hieny, S;Sher, A
通讯作者：
Sher, A
DOI：
10.1073/pnas.052533799
发表时间：
2002-03-19
影响因子：
11.1
作者：
Canny, G;Levy, O;Colgan, SP
通讯作者：
Colgan, SP
影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
3.5
作者：
BREZINSKI, ME;GIMBRONE, MA;SERHAN, CN
通讯作者：
SERHAN, CN