Alteration of non-protein respiratory quotient after hepatocellular carcinoma treatment can be related to des-γ-carboxy prothrombin before treatment.
Alteration of non-protein respiratory quotient after hepatocellular carcinoma treatment can be related to des-γ-carboxy prothrombin before treatment.
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DOI：
10.1186/2193-1801-1-55
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Azuma T
中科院分区：
文献类型：
--
作者：
Saito M;Seo Y;Yano Y;Miki A;Momose K;Hirano H;Yoshida M;Azuma T
经导管动脉化疗栓塞术（TACE）是治疗肝细胞癌（HCC）的有效方法，但治疗性低氧应激偶尔会导致能量营养不良。我们的目的是阐明TACE后能量营养不良与TACE前非肿瘤肝脏缺氧耐受性低之间的相关性。我们进行了一项前瞻性队列研究，涉及100例在科比大学医院接受TACE的HCC患者。在TACE前和术后7天进行间接量热，并测量非蛋白呼吸商（npRQ）作为能量营养不良的指标。TACE前还进行了血液生化检查。TACE前测定脱-γ-羧基凝血酶原（DCP）作为缺氧标志物。对npRQ比值（TACE后/前7天）和DCP（TACE前）之间的相关性进行了统计学检查。斯皮尔曼相关系数检验显示，npRQ比值（第7天/第0天）与DCP（第0天）显著相关（p=0.0481，r=-0.2033）。另一方面，npRQ比值（第7天/第0天）与甲胎蛋白（第0天）无关（p=0.6254，r=-0.0494）。TACE后npRQ的降低与TACE前DCP的高值相关。TACE后能量营养不良可能源于非肿瘤肝脏对缺氧耐受性差。TACE前DCP值高的HCC患者，临床上TACE后能量营养不良的风险较高。
Transcatheter arterial chemoembolization (TACE) is an effective treatment for hepatocellular carcinoma (HCC) that would occasionally lead to energy malnutrition through therapeutic hypoxic stress. We aimed to clarify the correlation between the energy malnutrition after TACE and low tolerability for hypoxia of non-tumoral liver before TACE. We performed a prospective cohort study involving 100 HCC patients who underwent TACE at Kobe University Hospital. Indirect calorimetry was performed before and 7 days after TACE, and non-protein respiratory quotient (npRQ) as an indicator of the energy malnutrition was measured. Blood biochemical examinations were also performed before TACE. As an indicator of hypoxic marker, des-γ-carboxy prothrombin (DCP) was measured before TACE. The correlation between npRQ ratio (7 days after/before TACE) and DCP (before TACE) was statistically examined. Spearman’s correlation coefficient test showed that npRQ ratio (Day 7/Day 0) was significantly related to DCP (Day 0) (p=0.0481, r=-0.2033). On the other hand, npRQ ratio (Day 7/Day 0) was not related to alpha fetoprotein (Day 0) (p=0.6254, r=-0.0494). The npRQ reduction after TACE was related to a high value of DCP before TACE. The energy malnutrition after TACE would originate from low tolerability for hypoxia of non-tumoral liver. The HCC patients with a high value of DCP before TACE would clinically have a high risk of the energy malnutrition after TACE.
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影响因子：
6.3
作者：
Saito, Masaya;Seo, Yasushi;Azuma, Takeshi
通讯作者：
Azuma, Takeshi
影响因子：
158.5
作者：
LIEBMAN, HA;FURIE, BC;FURIE, B
通讯作者：
FURIE, B
影响因子：
4.4
作者：
Tajika, M;Kato, M;Moriwaki, H
通讯作者：
Moriwaki, H
影响因子：
5.2
作者：
Murata, Kazumoto;Suzuki, Hideto;Sakamoto, Atsushi
通讯作者：
Sakamoto, Atsushi
影响因子：
6.3
作者：
Saito, Masaya;Seo, Yasushi;Azuma, Takeshi
通讯作者：
Azuma, Takeshi