Early onset of fatty liver in growth-restricted rat fetuses and newborns.
Early onset of fatty liver in growth-restricted rat fetuses and newborns.
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DOI：
10.1111/j.1741-4520.2011.00336.x
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发表时间：
2011-12
影响因子：
1.3
通讯作者：
Desai M
中科院分区：
文献类型：
--
作者：
Yamada M;Wolfe D;Han G;French SW;Ross MG;Desai M
宫内生长受限（IUGR）新生儿患成人代谢综合征（包括脂肪肝）的风险增加。然而，目前尚不清楚脂肪肝的发展是“程序化的”还是继发于伴随的肥胖。在本研究中，我们检测了IUGR和对照胎（胚胎第20天；e20）和新生（出生后第1天；p1）大鼠幼鼠的肝脏脂质积累和脂质调节因子（甾醇调节元件结合蛋白-1c和脂肪酸合成酶）。值得注意的是，尽管在子宫营养不良状态下，IUGR胎儿早在20岁时就表现出“脂肪肝”，这些脂肪生成指数上调。IUGR组和对照组新生儿的肝脏脂质含量均出现相同程度的大量增加，而IUGR组新生儿的脂肪生成指数继续上调。胎儿和新生儿IUGR中脂肪生成指数的持续上调表明脂肪肝是妊娠程序化的。我们的研究表明，IUGR后代出生时代谢生命策略发生改变，燃料/脂质储存增加，这可能是节俭表型的一种独特代谢途径。
Intrauterine growth restricted (IUGR) newborns have increased risk of adult metabolic syndrome, including fatty liver. However, it is unclear whether the fatty liver development is “programmed” or secondary to the accompanying obesity. In this study, we examined hepatic lipid accumulation and lipid-regulatory factors (sterol regulatory element-binding protein-1c and fatty acid synthase) in IUGR and Control fetal (embryonic day 20; e20) and newborn (postnatal day 1; p1) rat pups. Notably, despite of in utero undernutrition state, IUGR fetuses demonstrated ‘fatty liver’ with upregulation of these lipogenic indices at as early as e20. Both IUGR and Control newborns exhibited the same extent of massive increase in hepatic lipid content whereas IUGR newborns continued to exhibit upregulated lipogenic indices. The persistent upregulation of the lipogenic indices in fetal and newborn IUGR suggests that fatty liver is gestationally programmed. Our study suggested that IUGR offspring were born with an altered metabolic life strategy of increased fuel/lipid storage which could be a distinct metabolic pathway of the thrifty phenotype.
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影响因子：
15.9
作者：
Donnelly, KL;Smith, CI;Parks, EJ
通讯作者：
Parks, EJ
影响因子：
9.8
作者：
Desai, M;Gayle, D;Ross, MG
通讯作者：
Ross, MG
影响因子：
9.8
作者：
Abdel-Hakeem, Ahmed K.;Henry, Tasmia Q.;Magee, Thomas R.;Desai, Mina;Ross, Michael G.;Mansano, Roy Z.;Torday, John S.;Nast, Cynthia C.
通讯作者：
Nast, Cynthia C.
影响因子：
2.9
作者：
Desai, Mina;Han, Guang;Lane, Robert H.
通讯作者：
Lane, Robert H.
DOI：
10.1159/000242605
发表时间：
1986-01-01
期刊：
BIOLOGY OF THE NEONATE
影响因子：
--
作者：
GIRARD, J
通讯作者：
GIRARD, J