High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2.
High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2.
复制标题
DOI：
10.3390/v13112177
复制
发表时间：
2021-10-28
期刊：
影响因子：
--
通讯作者：
La Scola B
中科院分区：
文献类型：
--
作者：
Jaafar R;Boschi C;Aherfi S;Bancod A;Le Bideau M;Edouard S;Colson P;Chahinian H;Raoult D;Yahi N;Fantini J;La Scola B
背景：自COVID-19大流行开始以来，相继出现了几种SARS-CoV-2变体。在法国，大多数病例是由于携带刺突D 641 G的病毒，最初来自武汉毒株，然后是自2020年夏季以来我们称为马赛-4的B.1.160谱系变异株，随后是2021年初的α和β变异株，然后是目前的Delta变异株。研究方法：我们测定了先前感染这四种主要本地变异株的恢复期个体以及接种原始武汉毒株和九种变异株（包括两种最近流行的Delta分离株）的疫苗接种者血清中的中和抗体（nAb）滴度。结果：结果显示nAb的个体间异质性较高，特别是根据检测的变体。nAb之间的主要变异是基于负责感染的基因型。先前感染β和B.1.160变体的患者具有最低的nAb滴度。我们表明，这种异质性很好地解释了刺突蛋白突变体建模使用在硅片的方法。在接种辉瑞/BioNTech COVID-19疫苗的个体中观察到最高滴度，即使是针对δ变体。结论：感染后自然获得的免疫力高度依赖于感染变体，并且出乎意料地，基于mRNA的疫苗效力显示在引发中和抗体方面通常优于天然免疫力。
Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies.
登录
查看更多内容
影响因子：
64.5
作者：
Hoffmann M;Arora P;Groß R;Seidel A;Hörnich BF;Hahn AS;Krüger N;Graichen L;Hofmann-Winkler H;Kempf A;Winkler MS;Schulz S;Jäck HM;Jahrsdörfer B;Schrezenmeier H;Müller M;Kleger A;Münch J;Pöhlmann S
通讯作者：
Pöhlmann S
DOI：
10.1016/j.jcv.2020.104690
发表时间：
2021-01
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Coste AT;Jaton K;Papadimitriou-Olivgeris M;Greub G;Croxatto A
通讯作者：
Croxatto A
影响因子：
17.1
作者：
Jones BE;Brown-Augsburger PL;Corbett KS;Westendorf K;Davies J;Cujec TP;Wiethoff CM;Blackbourne JL;Heinz BA;Foster D;Higgs RE;Balasubramaniam D;Wang L;Zhang Y;Yang ES;Bidshahri R;Kraft L;Hwang Y;Žentelis S;Jepson KR;Goya R;Smith MA;Collins DW;Hinshaw SJ;Tycho SA;Pellacani D;Xiang P;Muthuraman K;Sobhanifar S;Piper MH;Triana FJ;Hendle J;Pustilnik A;Adams AC;Berens SJ;Baric RS;Martinez DR;Cross RW;Geisbert TW;Borisevich V;Abiona O;Belli HM;de Vries M;Mohamed A;Dittmann M;Samanovic MI;Mulligan MJ;Goldsmith JA;Hsieh CL;Johnson NV;Wrapp D;McLellan JS;Barnhart BC;Graham BS;Mascola JR;Hansen CL;Falconer E
通讯作者：
Falconer E
DOI：
10.1007/s10096-020-03913-9
发表时间：
2020-04-27
影响因子：
4.5
作者：
La Scola, Bernard;Le Bideau, Marion;Raoult, Didier
通讯作者：
Raoult, Didier
影响因子：
7.2
作者：
Hasan A;Al-Ozairi E;Al-Baqsumi Z;Ahmad R;Al-Mulla F
通讯作者：
Al-Mulla F