UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores
UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores
复制标题
UV-C 照射通过将 Mps1 招募到着丝粒来延迟有丝分裂进程
DOI：
10.4161/cc.24403
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发表时间：
2013-03
期刊：
影响因子：
4.3
通讯作者：
Quanbin Xu
中科院分区：
文献类型：
--
作者：
Runlin Z. Ma;Hui Zhong;Cheng Cao;Quanbin Xu
紫外线照射在间期对复制细胞的影响已被广泛研究。然而，有丝分裂细胞对紫外线照射如何反应还不太明确。在此，我们发现短波紫外线（254纳米）照射增加了……的募集（此处句子不完整，最后一个单词“s”不知道具体指代什么）
The effect of UV irradiation on replicating cells during interphase has been studied extensively. However, how the mitotic cell responds to UV irradiation is less well defined. Herein, we found that UV-C irradiation (254 nm) increases recruitment of the spindle checkpoint proteins Mps1 and Mad2 to the kinetochore during metaphase, suggesting that the spindle assembly checkpoint (SAC) is reactivated. In accordance with this, cells exposed to UV-C showed delayed mitotic progression, characterized by a prolonged chromosomal alignment during metaphase. UV-C irradiation also induced the DNA damage response and caused a significant accumulation of γ-H2AX on mitotic chromosomes. Unexpectedly, the mitotic delay upon UV-C irradiation is not due to the DNA damage response but to the relocation of Mps1 to the kinetochore. Further, we found that UV-C irradiation activates Aurora B kinase. Importantly, the kinase activity of Aurora B is indispensable for full recruitment of Mps1 to the kinetochore during both prometaphase and metaphase. Taking these findings together, we propose that UV irradiation delays mitotic progression by evoking the Aurora B-Mps1 signaling cascade, which exerts its role through promoting the association of Mps1 with the kinetochore in metaphase.
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有丝分裂纺锤体的紫外微束辐照。 ii。主轴纤维动力学和力产生。
影响因子：
7.8
作者：
Spurck, T P;Stonington, O G;Snyder, J A;Pickett-Heaps, J D;Bajer, A;Mole-Bajer, J
通讯作者：
Mole-Bajer, J
影响因子：
44.1
作者：
Dou, Z;Sawagechi, A;Yao, XB
通讯作者：
Yao, XB
DOI：
10.1083/jcb.201003038
发表时间：
2010-10-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Jelluma N;Dansen TB;Sliedrecht T;Kwiatkowski NP;Kops GJ
通讯作者：
Kops GJ
影响因子：
3.7
作者：
Dou Z;von Schubert C;Körner R;Santamaria A;Elowe S;Nigg EA
通讯作者：
Nigg EA
DOI：
10.1074/jbc.m111.267690
发表时间：
2011-08
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
Wei Zhang;G. Peng;Shiaw-Yih Lin;Pumin Zhang
通讯作者：
Wei Zhang;G. Peng;Shiaw-Yih Lin;Pumin Zhang