When and why women might suspend PrEP use according to perceived seasons of risk: implications for PrEP-specific risk-reduction counselling.
When and why women might suspend PrEP use according to perceived seasons of risk: implications for PrEP-specific risk-reduction counselling.
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DOI：
10.1080/13691058.2016.1164899
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Corneli A
中科院分区：
文献类型：
--
作者：
Namey E;Agot K;Ahmed K;Odhiambo J;Skhosana J;Guest G;Corneli A
使用抗逆转录病毒药物恩曲他滨/富马酸替诺福韦二异丙酯（Truvada）的口服暴露前预防（PrEP）已被证明可以显著降低感染风险较高的妇女感染艾滋病毒的风险，如果每天服用。了解女性在“正常”日常生活中何时以及为什么会故意停止使用有效的口服PrEP药物，对于提供有效的PrEP风险降低咨询至关重要。作为一项更大研究的一部分，我们对肯尼亚邦多和南非比勒陀利亚的艾滋病毒高风险妇女进行了60次定性访谈。参与者记录了他们在过去六个月的性接触，表明他们是否会在可用的情况下采取PrEP，并讨论了他们是否以及为什么会暂停使用PrEP。几乎所有的参与者都表示他们会在过去的六个月里使用PrEP;一半的人表示他们会在某个时候暂停使用PrEP。参与者延长PrEP休息时间的原因与伙伴关系动态有关（例如，感知的稳定伴侣的低风险）和生命阶段（例如，试着想象）。生活事件（例如，假期和旅行）可能会导致PrEP使用的中断时间缩短。这些情况可能与低风险的实际情况相对应，也可能不对应，突出了量身定制的PrEP风险降低咨询的重要性。
Oral pre-exposure prophylaxis (PrEP) using the antiretroviral drug emtricitabine/tenofovir disoproxil fumarate (Truvada) has been shown to dramatically reduce the risk of HIV acquisition for women at higher risk of infection if taken daily. Understanding when and why women would intentionally stop using an efficacious oral PrEP drug within the context of their “normal” daily lives is essential for delivering effective PrEP risk-reduction counselling. We conducted 60 qualitative interviews with women at higher risk of HIV in Bondo, Kenya, and Pretoria, South Africa, as part of a larger study. Participants charted their sexual contacts over the previous six months, indicated whether they would have taken PrEP if available, and discussed whether and why they would have suspended PrEP use. Nearly all participants said they would have used PrEP in the previous six months; half indicated they would have suspended PrEP use at some point. Participants’ reasons for an extended break from PrEP were related to partnership dynamics (e.g., perceived low risk of a stable partner) and phases of life (e.g., trying to conceive). Life events (e.g., holidays and travel) could prompt shorter breaks in PrEP use. These circumstances may or may not correspond to actual contexts of lower risk, highlighting the importance of tailored PrEP risk-reduction counselling.
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DOI：
10.1097/qad.0b013e32834a9338
发表时间：
2011-09-24
期刊：
AIDS (London, England)
影响因子：
--
作者：
Mugo NR;Heffron R;Donnell D;Wald A;Were EO;Rees H;Celum C;Kiarie JN;Cohen CR;Kayintekore K;Baeten JM;Partners in Prevention HSV/HIV Transmission Study Team
通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
影响因子：
5.4
作者：
Chimbiri, Agnes M.
通讯作者：
Chimbiri, Agnes M.
影响因子：
120.7
作者：
Mugo, Nelly R.;Hong, Ting;Baeten, Jared M.
通讯作者：
Baeten, Jared M.
影响因子：
11.8
作者：
Seifert, Sharon M.;Glidden, David V.;Anderson, Peter L.
通讯作者：
Anderson, Peter L.
影响因子：
1.5
作者：
Domanska, Catherine A.;Teitelman, Anne M.
通讯作者：
Teitelman, Anne M.