The genomewide transcriptional response underlying the pea aphid wing polyphenism.
The genomewide transcriptional response underlying the pea aphid wing polyphenism.
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DOI：
10.1111/mec.13749
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发表时间：
2016-09
影响因子：
4.9
通讯作者：
Brisson JA
中科院分区：
文献类型：
--
作者：
Vellichirammal NN;Madayiputhiya N;Brisson JA
表型可塑性是许多生活在异质环境中的动植物所采用的一种关键的生活史策略。许多研究已经调查了可塑性的成本和限制，以及它演变的条件。更不为人所知的是使生物体能够感知其环境并以可塑性方式做出反应的分子遗传机制。豌豆蚜虫翅多型是一个令人信服的实验室模型来研究这些机制。在这种多型性中，环境压力如高密度导致无性、胎生的成年雌性蚜虫将其胚胎的发育从无翅型改变为有翅型。这两种变体之间的生活史权衡已被深入研究，但这一过程背后的分子机制仍在很大程度上未知。因此，我们进行了一个全基因组研究的母体转录组在两个时间点，拥挤的压力和没有发现母体分子的变化，导致有翼与无翼后代的发展。我们观察到显着的基因转录变化与气味结合，神经递质转运，激素活性，染色质重塑在母体转录组。我们还发现，血清素，多巴胺和章鱼胺的滴度更高，在孤独相比，拥挤的蚜虫。我们利用这些结果来建立一个模型，以了解母体信号如何告知发育中的胚胎是有翼还是无翼。我们的研究结果增加了显着的见解的身份的分子机制，环境诱导的形态决定，并建议生物胺调节在多型化一般可能发挥的作用。
Phenotypic plasticity is a key life history strategy used by many plants and animals living in heterogeneous environments. A multitude of studies have investigated the costs and limits of plasticity, as well as the conditions under which it evolves. Much less well understood are the molecular genetic mechanisms that enable an organism to sense its environment and respond in a plastic manner. The pea aphid wing polyphenism is a compelling laboratory model to study these mechanisms. In this polyphenism, environmental stressors like high density cause asexual, viviparous adult female aphids to change the development of their embryos from wingless to winged morphs. The life history tradeoffs between the two morphs have been intensively studied, but the molecular mechanisms underlying this process remain largely unknown. We therefore performed a genome-wide study of the maternal transcriptome at two time points with and without a crowding stress to discover the maternal molecular changes that lead to the development of winged versus wingless offspring. We observed significant transcriptional changes in genes associated with odorant binding, neurotransmitter transport, hormonal activity, and chromatin remodeling in the maternal transcriptome. We also found that titers of serotonin, dopamine, and octopamine were higher in solitary compared to crowded aphids. We use these results to posit a model for how maternal signals inform a developing embryo to be winged or wingless. Our findings add significant insights into the identity of the molecular mechanisms that underlie environmentally induced morph determination and suggest a possible role for biogenic amine regulation in polyphenisms generally.
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影响因子：
23.9
作者：
Ables, Elizabeth T.;Drummond-Barbosa, Daniela
通讯作者：
Drummond-Barbosa, Daniela
影响因子：
1.6
作者：
HIRASHIMA, A;NAGANO, T;ETO, M
通讯作者：
ETO, M
影响因子：
2.1
作者：
通讯作者：
--
影响因子：
0.9
作者：
Iba, M;Nagao, T;Urano, A
通讯作者：
Urano, A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y