The association of wall mechanics and morphology: a case study of abdominal aortic aneurysm growth.
The association of wall mechanics and morphology: a case study of abdominal aortic aneurysm growth.
复制标题
壁力学与形态学的关联：腹主动脉瘤生长的案例研究。
DOI：
10.1115/1.4005176
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Finol,EnderA
中科院分区：
文献类型：
--
作者：
Washington,ChristopherB;Shum,Judy;Muluk,SatishC;Finol,EnderA
本研究的目的是评估峰值壁应力（PWS）和腹主动脉瘤（AAA）形态之间的潜在相关性以及它与动脉瘤破裂可能性的关系。使用内部分割和网格划分软件，生成了来自单个患者的 6 个 3 维 (3D) AAA 模型，并进行了 28 个月的跟踪，用于有限元分析。对于 AAA 壁，使用了各向同性和各向异性材料，而各向同性材料用于管腔内血栓 (ILT)。这些模型还用于计算动脉瘤形态特征的 36 个几何指数。使用最小二乘回归，发现七个显着的几何特征 (p<0.05) 可以表征监测期间的 AAA 形态。通过非线性回归，发现用各向异性材料估计的 PWS 与以下三个特征高度相关：最大直径（r = 0.992，p = 0.002）、囊体积（r = 0.989，p = 0.003）和直径与直径比（r = 0.947， p = 0.033）。壁力学与几何形状的相关性是非线性的，表明 PWS 不会随着动脉瘤直径的增加而增加。这表明 AAA 形态的定量表征可能有利于评估破裂风险。
The purpose of this study is to evaluate the potential correlation between peak wall stress (PWS) and abdominal aortic aneurysm (AAA) morphology and how it relates to aneurysm rupture potential. Using in-house segmentation and meshing software, six 3-dimensional (3D) AAA models from a single patient followed for 28 months were generated for finite element analysis. For the AAA wall, both isotropic and anisotropic materials were used, while an isotropic material was used for the intraluminal thrombus (ILT). These models were also used to calculate 36 geometric indices characteristic of the aneurysm morphology. Using least squares regression, seven significant geometric features (p < 0.05) were found to characterize the AAA morphology during the surveillance period. By means of nonlinear regression, PWS estimated with the anisotropic material was found to be highly correlated with three of these features: maximum diameter (r = 0.992, p = 0.002), sac volume (r = 0.989, p = 0.003) and diameter to diameter ratio (r = 0.947, p = 0.033). The correlation of wall mechanics with geometry is nonlinear and reveals that PWS does not increase concomitantly with aneurysm diameter. This suggests that a quantitative characterization of AAA morphology may be advantageous in assessing rupture risk.
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影响因子：
2.8
作者：
Giannoglou, G.;Giannakoulas, G.;Louridas, G.
通讯作者：
Louridas, G.
影响因子：
4.3
作者：
Fillinger, MF;Marra, SP;Kennedy, FE
通讯作者：
Kennedy, FE
DOI：
10.1080/1025584021000009742
发表时间：
2002-08-01
影响因子：
1.6
作者：
Finol, Ender A;Amon, Cristina H
通讯作者：
Amon, Cristina H
影响因子：
4.3
作者：
Fillinger, MF;Raghavan, ML;Kennedy, FE
通讯作者：
Kennedy, FE
DOI：
10.1016/j.ejvs.2004.03.029
发表时间：
2004-08-01
影响因子：
5.7
作者：
Venkatasubramaniam, AK;Fagan, MJ;McCollum, PT
通讯作者：
McCollum, PT