Effects of acute hyperthermia on the carotid baroreflex control of heart rate in humans
Effects of acute hyperthermia on the carotid baroreflex control of heart rate in humans
复制标题
急性高热对颈动脉压力反射控制心率的影响
DOI：
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发表时间：
1997
影响因子：
3.2
通讯作者：
K. Shiraki
中科院分区：
文献类型：
--
作者：
F. Yamazaki;S. Sagawa;R. Torii;Y. Endo;K. Shiraki
摘要本研究旨在探讨高温对人体颈动脉压力感受器-心脏反射的影响。 9名健康男性接受了由热水灌注服产生的急性高温（食管温度> 38.0° C）。在正常体温和体温过高期间，在+40至−65 mm Hg的正R波和负R波触发颈部压力阶跃期间测定心跳至心跳心率（HR）反应。颈动脉压力感受器-心脏反射敏感性从HR对颈动脉扩张压力变化的反应的最大斜率来评价。根据参考点（0 mm Hg颈部压力下的HR-最小HR）/HR范围×100，评价HR对颈动脉扩张压力反应的缓冲能力（%）。在体温过高时，心率曲线明显上移，因为心率从正常体温时的57.7±2.4次/min增加到体温过高时的88.7±4.1次/min（P<0.05），而平均动脉压没有变化。体温过高时曲线的最大斜率与体温正常时相似。热疗时参考点升高（P<0.05）。这些结果表明，颈动脉压力感受器反射的敏感性在高温保持不变。然而，在急性高热期间，对低血压快速发作的心动过速反应能力降低，对突发高血压的心动过缓反应能力增加。
Abstract The purpose of this study was to examine the effect of hyperthermia on the carotid baroreceptor-cardiac reflexes in humans. Nine healthy males underwent acute hyperthermia (esophageal temperature ∼38.0° C) produced by hot water-perfused suits. Beat-to-beat heart rate (HR) responses were determined during positive and negative R-wave-triggered neck pressure steps from +40 to −65 mm Hg during normothermia and hyperthermia. The carotid baroreceptor-cardiac reflex sensitivity was evaluated from the maximum slope of the HR response to changes in carotid distending pressure. Buffering capacity of the HR response to carotid distending pressure was evaluated in % from a reference point calculated as (HR at 0 mm Hg neck pressure−minimum HR)/HR range ×100. An upward shift of the curve was evident in hyperthermia because HR increased from 57.7±2.4 beats/min in normothermia to 88.7±4.1 beats/min in hyperthermia (P<0.05) without changes in mean arterial pressure. The maximum slope of the curve in hyperthermia was similar to that in normothermia. The reference point was increased (P<0.05) during hyperthermia. These results suggest that the sensitivity of the carotid baroreflex of HR remains unchanged in hyperthermia. However, the capacity for tachycardia response to rapid onset of hypotension is reduced and the capacity for bradycardia response to sudden hypertension is increased during acute hyperthermia.
影响因子：
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作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
用于快速量化人类颈动脉压力感受器心脏反射反应的装置。
DOI：
10.1152/jappl.1986.60.2.727
发表时间：
1986
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Sprenkle,JM;Eckberg,DL;Goble,RL;Schelhorn,JJ;Halliday,HC
通讯作者：
Halliday,HC