Anxiety, Depression, and Social Skills in Girls with Fragile X Syndrome: Understanding the Cycle to Improve Outcomes.
Anxiety, Depression, and Social Skills in Girls with Fragile X Syndrome: Understanding the Cycle to Improve Outcomes.
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DOI：
10.1097/dbp.0000000000001128
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发表时间：
2022-12-01
影响因子：
2.4
通讯作者：
Reiss, Allan L. L.
中科院分区：
文献类型：
--
作者：
Lightbody, Amy A. A.;Bartholomay, Kristi L. L.;Jordan, Tracy L. L.;Lee, Cindy H. H.;Miller, Jonas G. G.;Reiss, Allan L. L.
患有脆性X综合征(FXS)的女性患焦虑和抑郁的风险显著增加。FXS是一种与FMR1基因突变相关的遗传疾病。这项研究旨在更好地了解学龄女孩的这些症状，特别是当它们与年龄、社交技能和功能结果有关时。我们比较了58名患有FXS的6-16岁女孩和46名年龄、性别和发育相匹配的没有FXS的同龄人在焦虑、抑郁、社交技能、适应行为和生活质量方面的指标。患有10.5岁及以上FXS的女孩比10.5岁以下的FXS女孩表现出更高的抑郁、退缩和社交回避水平(p‘s<；.01)。对照组的女孩在这些测量上没有表现出任何与年龄相关的差异。年长的FXS队列还显示了社交和互动技能、适应行为以及焦虑和抑郁的测量(p‘s<；0.05)之间的关联，这在对照组中是看不到的，与年龄无关。我们发现，年龄似乎在情绪症状的发展中扮演着重要的角色，而且这些症状与青春期后FXS女孩的社交交流和互惠社交行为以及适应功能具有独特的相关性。这些数据表明，FXS女孩在改善社交技能和预防社交回避以及焦虑和抑郁症状方面是一个关键的干预窗口，最终目标是提高生活质量和促进更大的独立性。
Females with fragile X syndrome (FXS), a genetic condition associated with a mutation in the FMR1 gene, are at significantly elevated risk for developing anxiety and depression. This study is designed to better understand these symptoms in school-aged girls, particularly as they relate to age, social skills, and functional outcomes. We compared 58 girls ages 6–16 years with FXS to 46 age-, gender-, and developmentally-matched peers without FXS on measures of anxiety, depression, social skills, adaptive behavior, and quality of life. Girls with FXS 10.5 years and older demonstrated significantly higher levels of depression, withdrawal, and social avoidance than girls younger than 10.5 with FXS (p’s < .01). Girls in the comparison group did not show any age-related differences on these measures. The older FXS cohort also showed associations between social communication and interaction skills, adaptive behavior, and measures of anxiety and depression (p’s < .05) not seen in the comparison group, regardless of age. We found that age appears to play an important role in the development of mood symptoms and that such symptoms are uniquely correlated with social communication and reciprocal social interaction behaviors and adaptive functioning in girls with FXS post-puberty. These data suggest a critical window of intervention for girls with FXS in the improvement of social interaction skills and the prevention of social avoidance and symptoms of anxiety and depression, with the ultimate goal of improving quality of life and promoting greater independence.
影响因子：
1.8
作者：
Biro FM;Huang B;Daniels SR;Lucky AW
通讯作者：
Lucky AW