Pubarche as well as thelarche may be a marker for the onset of puberty.
Pubarche as well as thelarche may be a marker for the onset of puberty.
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DOI：
10.1016/j.jpag.2007.09.008
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发表时间：
2008-12
影响因子：
1.8
通讯作者：
Lucky AW
中科院分区：
文献类型：
--
作者：
Biro FM;Huang B;Daniels SR;Lucky AW
定义一组仅以乳房发育（“乳房初长”途径）开始青春期的黑人和白人女孩与仅以阴毛发育（“阴毛初长”途径）开始青春期的黑人和白人女孩的人体测量学和激素差异，并检验阴毛初长可能代表真正的青春期发育的假设。纵向队列，每年观察一次，持续10年。通过俄亥俄州辛辛那提和加利福尼亚州里士满的小学招募;通过华盛顿特区的HMO招募。9岁，黑人或白色，在NHLBI生长和健康研究。无;观察性研究。青春期开始时的最初第二性征;人体测量;激素测量。1155名女孩中有478名通过确定的途径成熟。第二性征的发病年龄在不同途径之间是相似的，尽管乳房发育途径中的女孩在更小的年龄进入青春期，而黑人参与者进入青春期的年龄要小得多。身高速度是相同的，在这两个途径，并在青春期的范围。在青春期开始时，DHEA-S水平在阴毛初现途径中的女孩中显著更高，但雌二醇和睾酮水平没有差异。初潮年龄因种族（黑人较年轻）和途径（乳房初潮途径较年轻）而不同。考虑到第二性征出现时相似的年龄和身高速度，这些结果表明，阴毛初长，即阴毛的发育而没有乳房的发育，可能代表了真正的青春期成熟。
To define anthropometric and hormonal differences in a group of black and white girls who began puberty with breast development alone (“thelarche” pathway) compared to those who began with pubic hair development alone (“pubarche” pathway), and test the hypothesis that pubarche may represent true pubertal development. Longitudinal cohort seen annually for ten years. Recruited through elementary schools in Cincinnati OH and Richmond CA; through HMO in Washington DC. 9 years old, either Black or White, in the NHLBI Growth and Health Study. None; observational study. Initial secondary sexual characteristic at onset of puberty; anthropometric measures; hormone measures. 478 of 1155 girls matured through a defined pathway. Age at onset of secondary sexual characteristics was similar between pathways, although girls in the thelarche pathway had puberty at a somewhat younger age, and black participants entered at a significantly younger age. Height velocity was the same in both pathways, and in the pubertal range. DHEA-S levels at onset of puberty were significantly greater in girls in the pubarche pathway, but levels of estradiol and testosterone were not different. Age of menarche was different by race (younger in blacks) and pathway (younger in thelarche pathway). Given similar age and height velocities at onset of secondary sexual characteristics, these results suggest that pubarche, the development of pubic hair without breast development, may represent true pubertal maturation.
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影响因子：
--
作者：
ROSENFIELD, RL
通讯作者：
ROSENFIELD, RL
影响因子：
20.3
作者：
SIMPSON, ER;MERRILL, JC;MENDELSON, CR
通讯作者：
MENDELSON, CR
影响因子：
2.9
作者：
Vizmanos, B;Martí-Henneberg, C;Fernández-Ballart, J
通讯作者：
Fernández-Ballart, J
影响因子：
5.8
作者：
DERIDDER, CM;THIJSSEN, JHH;ERICH, WBM
通讯作者：
ERICH, WBM
影响因子：
8
作者：
Sun, SMS;Schubert, CM;Ryan, AS
通讯作者：
Ryan, AS