The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
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DOI：
10.1038/ni.2767
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发表时间：
2014-01
影响因子：
30.5
通讯作者：
Brown, Brian D.
中科院分区：
文献类型：
--
作者：
Agudo, Judith;Ruzo, Albert;Tung, Navpreet;Salmon, Helene;Leboeuf, Marylene;Hashimoto, Daigo;Becker, Christian;Garrett-Sinha, Lee-Ann;Baccarini, Alessia;Merad, Miriam;Brown, Brian D.
microRNA -126 （miR-126）是一种主要由内皮细胞表达并控制血管生成的microRNA。我们发现miR-126是对病原体相关核酸的先天反应所必需的，并且miR-126缺陷的小鼠对伪hiv感染的易感性增加。miRNA分析和深度测序表明，miR-126在浆细胞样树突状细胞（pDCs）中高度特异性表达。miR-126控制着pDCs的存活和功能，并调节包括Tlr7、Tlr9和Nfkb1在内的应答基因以及编码vegf受体2 （VEGFR2）的Kdr的表达。dc中Kdr的缺失导致I型干扰素产生减少，支持VEGFR2在miR-126调控dc中的作用。这些研究发现miR-126-VEGFR2轴是先天反应的重要调节因子，通过多尺度控制pDCs发挥作用。
MicroRNA-126 (miR-126) is a microRNA predominately expressed by endothelial cells and controls angiogenesis. We found miR-126 was required for the innate response to pathogen-associated nucleic acids, and that miR-126-deficient mice had increased susceptibility to pseudotyped-HIV infection. miRNA profiling and deep-sequencing indicated that miR-126 was highly and specifically expressed by plasmacytoid dendritic cells (pDCs). miR-126 controlled the survival and function of pDCs, and regulated expression ofinnate response genes, including Tlr7, Tlr9 and Nfkb1, as well as Kdr, which encodes VEGF-receptor 2 (VEGFR2). Deletion of Kdr in DCs resulted in reduced type I interferon production, supporting a role for VEGFR2 in miR-126 regulation of pDCs. These studies identify the miR-126–VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
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影响因子：
64.5
作者：
Chevrier N;Mertins P;Artyomov MN;Shalek AK;Iannacone M;Ciaccio MF;Gat-Viks I;Tonti E;DeGrace MM;Clauser KR;Garber M;Eisenhaure TM;Yosef N;Robinson J;Sutton A;Andersen MS;Root DE;von Andrian U;Jones RB;Park H;Carr SA;Regev A;Amit I;Hacohen N
通讯作者：
Hacohen N
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
15.9
作者：
Beignon, AS;McKenna, K;Bhardwaj, N
通讯作者：
Bhardwaj, N
影响因子：
4.4
作者：
Krug, A;Uppaluri, R;Colonna, M
通讯作者：
Colonna, M
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.