Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.
Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.
复制标题
DOI：
10.1088/1741-2560/11/5/056023
复制
发表时间：
2014-10
影响因子：
4
通讯作者：
Murphy DL
中科院分区：
文献类型：
--
作者：
Peterchev AV;DʼOstilio K;Rothwell JC;Murphy DL
本工作旨在实现经颅磁刺激（TMS）中灵活实用的脉冲参数控制，这在目前的商用设备中非常有限。我们提出了第三代可控脉冲参数器件（cTMS3），该器件采用新颖的电路拓扑结构和两个储能电容器。与传统的TMS设备和其他具有先进脉冲形状控制的设备相比，它具有几个实现和功能优势。cTMS3产生更低的内部电压差，并且使用比以前的cTMS器件具有更低额定电压的晶体管实现。cTMS3提供了更灵活的脉冲整形，因为电路拓扑允许在脉冲期间四个线圈电压电平，包括近似零电压。接近于零的线圈电压使得脉冲末端的振铃可以被缓冲，而不需要单独的有源缓冲电路。cTMS3可以通过增加每个后续脉冲的宽度和利用大电容储能来产生强大的快速脉冲序列（脉冲间隔<10 ms），从而实现双脉冲和四脉冲TMS等范例与单个脉冲产生电路。cTMS3还可以产生以单向电场脉冲为主的θ (50 Hz)脉冲刺激。cTMS3装置的功能和输出强度通过电输出测量以及脉冲宽度和极性对10名健康志愿者主动马达阈值影响的研究来说明。cTMS3的特征可以扩展经颅磁刺激作为研究、诊断和治疗工具的效用。
This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. We present a third generation controllable pulse parameter device (cTMS3) that uses a novel circuit topology with two energy-storage capacitors. It incorporates several implementation and functionality advantages over conventional TMS devices and other devices with advanced pulse shape control. cTMS3 generates lower internal voltage differences and is implemented with transistors with lower voltage rating than prior cTMS devices. cTMS3 provides more flexible pulse shaping since the circuit topology allows four coil-voltage levels during a pulse, including approximately zero voltage. The near-zero coil voltage enables snubbing of the ringing at the end of the pulse without the need for a separate active snubber circuit. cTMS3 can generate powerful rapid pulse sequences (<10 ms inter pulse interval) by increasing the width of each subsequent pulse and utilizing the large capacitor energy storage, allowing the implementation of paradigms such as paired-pulse and quadripulse TMS with a single pulse generation circuit. cTMS3 can also generate theta (50 Hz) burst stimulation with predominantly unidirectional electric field pulses. The cTMS3 device functionality and output strength are illustrated with electrical output measurements as well as a study of the effect of pulse width and polarity on the active motor threshold in 10 healthy volunteers. The cTMS3 features could extend the utility of TMS as a research, diagnostic, and therapeutic tool.
登录
查看更多内容
影响因子：
10.6
作者：
O'Reardon, John P.;Solvason, H. Brent;Sackeim, Harold A.
通讯作者：
Sackeim, Harold A.
神经元网络在驱动人类运动皮层可塑性中的作用
影响因子：
3.7
作者：
Hamada, Masashi;Murase, Nagako;Rothwelll, John C.
通讯作者：
Rothwelll, John C.
影响因子：
3.7
作者：
Goetz SM;Truong CN;Gerhofer MG;Peterchev AV;Herzog HG;Weyh T
通讯作者：
Weyh T
影响因子：
3.8
作者：
McIntyre, CC;Grill, WM
通讯作者：
Grill, WM
影响因子：
5.5
作者：
DAY, BL;DRESSLER, D;THOMPSON, PD
通讯作者：
THOMPSON, PD