The -842G/C polymorphisms of PIN1 contributes to cancer risk: a meta-analysis of 10 case-control studies.
The -842G/C polymorphisms of PIN1 contributes to cancer risk: a meta-analysis of 10 case-control studies.
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DOI：
10.1371/journal.pone.0071516
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li ZJ
中科院分区：
文献类型：
--
作者：
Xu HR;Xu ZF;Sun YL;Han JJ;Li ZJ
PIN1在肿瘤的发生发展中起着重要的作用。根据已发表的文献，PIN1基因−842G/C(Rs2233678)多态性与癌症风险的关系尚无定论。使用PubMed、EMbase和中国国家知识基础设施数据库检索截至2013年2月的文献。共有10项病例对照研究，包括4619例病例和4661例对照，帮助进行了定量分析。使用优势比(OR)和95%可信区间(95%CI)来评估关联强度。总体而言，与野生型GG相比，具有变异的CG(OR = 0.728，95%CI：0.585，0.906；P异质性)和CG/CC(OR = 0.731，95%CI：0.602，0.888；P异质性<；0.01)的个体的癌症风险显著降低。亚组分析显示，变异的CG(OR = 0.635，95%CI：0.548，0.735；P异质性 = 0.240)和CG/CC(OR = 0.645，95%CI：0.559，0.744，P异质性 = 0.258)等位基因在亚洲人中仍显示出降低癌症风险的作用；而在高加索人中未观察到明显的相关性(CG与GG：OR = 0.926，95%CI：0.572，1.499，P异质性及异质性；0.01；CG/CC VS GG：OR = 0.892，95%CI：0.589，1.353；敏感度分析进一步证实了结果的稳定性。贝格的漏斗图和埃格的测试没有揭示任何发表偏见。这一荟萃分析表明，PIN1−842G/C多态与显著降低癌症风险有关，特别是在亚洲人群中。
Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) plays an important role in cancer development. The relationship between PIN1 −842G/C (rs2233678) polymorphism and cancer risk was inconclusive according to published literature. A literature search, up to February 2013, was carried out using PubMed, EMBASE and the China National Knowledge Infrastructure (CNKI) database. A total of 10 case-control studies including 4619 cases and 4661 controls contributed to the quantitative analysis. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant CG (OR = 0.728, 95% CI: 0.585,0.906; Pheterogeneity<0.01) and CG/CC (OR = 0.731, 95% CI: 0.602,0.888; Pheterogeneity<0.01) genotypes were associated with a significantly reduced cancer risk compared with those with wild GG genotype. Sub-group analysis revealed that the variant CG (OR = 0.635, 95% CI: 0.548,0.735; Pheterogeneity = 0.240) and CG/CC (OR = 0.645, 95% CI: 0.559,0.744, Pheterogeneity = 0.258) genotypes still showed an reduced risk of cancer in Asians; while no significant association was observed in Caucasians (CG vs.GG: OR = 0.926, 95% CI: 0.572,1.499, Pheterogeneity<0.01; CG/CC vs. GG: OR = 0.892, 95% CI: 0.589,1.353; Pheterogeneity<0.01). Furthermore, sensitivity analysis confirmed the stability of results. Begg's funnel plot and Egger's test did not reveal any publication bias. This meta-analysis suggests that the PIN1 −842G/C polymorphism is associated with a significantly reduced risk of cancer, especially in Asian populations.
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影响因子：
6
作者：
Bao, L;Kimzey, A;Wang, DG
通讯作者：
Wang, DG
PIN1基因多态性和单倍型与中国南部和东部人群肺癌风险相关
影响因子：
3.9
作者：
Lu, Jiachun;Yang, Lei;Zhou, Yifeng
通讯作者：
Zhou, Yifeng
影响因子：
37.3
作者：
Lam PB;Burga LN;Wu BP;Hofstatter EW;Lu KP;Wulf GM
通讯作者：
Wulf GM
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
5.3
作者：
Chen, SY;Wulf, G;Balk, SP
通讯作者：
Balk, SP