COVID-19: A review of therapeutic strategies and vaccine candidates.
COVID-19: A review of therapeutic strategies and vaccine candidates.
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DOI：
10.1016/j.clim.2020.108634
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Sawalha AH
中科院分区：
文献类型：
--
作者：
Izda V;Jeffries MA;Sawalha AH
随着COVID-19成为全球主要死因之一，全球正陷入数十年来最广泛及最重大的公共卫生危机之一。引起COVID-19的新型SARS-CoV-2冠状病毒已将科学界团结起来，寻求治疗和预防解决方案。目前的首要任务有两个：第一，重新利用已经批准的药物或开发新的疗法，以减少与不断传播的病毒相关的发病率和死亡率。第二，科学界和更大的制药界的任务是开发、测试和生产安全有效的疫苗，作为长期解决方案，防止在人群中进一步传播和复发。本文的目的是回顾有关正在进行临床试验的主要药物治疗和正在开发的候选疫苗以遏制COVID-19威胁的最新公布数据。由SARS-CoV-2引起的大流行已成为全球死亡的主要原因。抗病毒药物瑞德西韦对因COVID-19住院并患有下呼吸道感染的患者有效。已经报道了许多重新利用免疫调节剂的临床试验的结果，地塞米松在严重COVID-19中的结果是积极的。有效的COVID-19疫苗的开发似乎是突出的。
The world is engulfed by one of the most widespread and significant public health crises in decades as COVID-19 has become among the leading causes of death internationally. The novel SARS-CoV-2 coronavirus which causes COVID-19 has unified the scientific community in search of therapeutic and preventative solutions. The top priorities at the moment are twofold: first, to repurpose already-approved pharmacologic agents or develop novel therapies to reduce the morbidity and mortality associated with the ever-spreading virus. Secondly, the scientific and larger pharmaceutical community have been tasked with the development, testing, and production of a safe and effective vaccine as a longer-term solution to prevent further spread and recurrence throughout the populace. The purpose of this article is to review the most up-to-date published data regarding both the leading pharmacological therapies undergoing clinical trials and vaccine candidates in development to stem the threat of COVID-19. A pandemic caused by SARS-CoV-2 has become a leading cause of death globally. The anti-viral agent remdesivir was effective in patients who were hospitalized with COVID-19 and had lower respiratory tract infection. The results of a number of clinical trials repurposing immunomodulatory agents have been reported, with positive results for dexamethasone in severe COVID-19. The development of an effective COVID-19 vaccine appears to be eminent.
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影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
REGN-COV2抗体预防和治疗恒河猕猴和仓鼠中的SARS-COV-2感染。
DOI：
10.1126/science.abe2402
发表时间：
2020-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Baum A;Ajithdoss D;Copin R;Zhou A;Lanza K;Negron N;Ni M;Wei Y;Mohammadi K;Musser B;Atwal GS;Oyejide A;Goez-Gazi Y;Dutton J;Clemmons E;Staples HM;Bartley C;Klaffke B;Alfson K;Gazi M;Gonzalez O;Dick E Jr;Carrion R Jr;Pessaint L;Porto M;Cook A;Brown R;Ali V;Greenhouse J;Taylor T;Andersen H;Lewis MG;Stahl N;Murphy AJ;Yancopoulos GD;Kyratsous CA
通讯作者：
Kyratsous CA
DOI：
10.1016/j.cmi.2020.09.014
发表时间：
2021-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Bartoletti M;Marconi L;Scudeller L;Pancaldi L;Tedeschi S;Giannella M;Rinaldi M;Bussini L;Valentini I;Ferravante AF;Potalivo A;Marchionni E;Fornaro G;Pascale R;Pasquini Z;Puoti M;Merli M;Barchiesi F;Volpato F;Rubin A;Saracino A;Tonetti T;Gaibani P;Ranieri VM;Viale P;Cristini F;PREDICO Study Group
通讯作者：
PREDICO Study Group
影响因子：
20.1
作者：
Donoghue, M;Hsieh, F;Acton, S
通讯作者：
Acton, S
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin