Interleukin-13 +1923C/T polymorphism is associated with asthma risk: a meta-analysis.
Interleukin-13 +1923C/T polymorphism is associated with asthma risk: a meta-analysis.
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Interleukin-13 1923C/T 多态性与哮喘风险相关：荟萃分析
DOI：
10.1155/2013/394316
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发表时间：
2013
影响因子：
--
通讯作者：
Xiu Q
中科院分区：
文献类型：
--
作者：
Liu Y;Liu T;Nie W;Lai G;Xiu Q
白细胞介素-13 (IL-13) +1923C/T 多态性 (rs1295686) 与哮喘风险之间的关系存在争议。我们进行这项研究是为了通过荟萃分析的方法评估这种关联。使用 PubMed、EMBASE 和中国知网 (CNKI) 进行了截至 2012 年 10 月 16 日的系统检索，确定了 10 项研究，包括 13698 例病例和 38209 例对照。计算了具有 95% 置信区间 (CI) 的合并比值比 (OR)。在共显性模型中，IL-13 +1923C/T 多态性与哮喘风险之间存在显着相关性。按种族分层时，IL-13 +1923C/T 多态性仍然与亚洲人和白种人较高的哮喘风险显着相关。在按研究质量进行的亚组分析中，在高质量研究中观察到哮喘风险显着增加。敏感性分析和累积分析进一步强化了结果的有效性。本荟萃分析未发现发表偏倚。总之，该荟萃分析的结果表明 IL-13 +1923C/T 多态性是哮喘的危险因素。
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. We performed this study to assess the association by the method of meta-analysis. A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. There was a significant association between IL-13 +1923C/T polymorphism and asthma risk in codominant model. When stratified by ethnicity, IL-13 +1923C/T polymorphism remained significantly associated with higher asthma risk in Asians and Caucasians. In the subgroup analysis by study quality, a significantly increased asthma risk was observed in high quality studies. Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this meta-analysis. In conclusion, results from this meta-analysis suggested that IL-13 +1923C/T polymorphism was a risk factor of asthma.
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影响因子：
4.5
作者：
Noguchi E;Sakamoto H;Hirota T;Ochiai K;Imoto Y;Sakashita M;Kurosaka F;Akasawa A;Yoshihara S;Kanno N;Yamada Y;Shimojo N;Kohno Y;Suzuki Y;Kang MJ;Kwon JW;Hong SJ;Inoue K;Goto Y;Yamashita F;Asada T;Hirose H;Saito I;Fujieda S;Hizawa N;Sakamoto T;Masuko H;Nakamura Y;Nomura I;Tamari M;Arinami T;Yoshida T;Saito H;Matsumoto K
通讯作者：
Matsumoto K
DOI：
10.1016/j.jaci.2011.09.029
发表时间：
2012-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Granada M;Wilk JB;Tuzova M;Strachan DP;Weidinger S;Albrecht E;Gieger C;Heinrich J;Himes BE;Hunninghake GM;Celedón JC;Weiss ST;Cruikshank WW;Farrer LA;Center DM;O'Connor GT
通讯作者：
O'Connor GT
细胞毒性 T 淋巴细胞相关抗原 4 多态性与哮喘风险：荟萃分析
影响因子：
3.7
作者：
Nie W;Chen J;Xiu Q
通讯作者：
Xiu Q
影响因子：
14.2
作者：
Maier, Lisa M.;Howson, Joanna M. M.;Strachan, David P.
通讯作者：
Strachan, David P.
影响因子：
5.3
作者：
Daley, Denise;Lemire, Mathieu;Hudson, Thomas J.
通讯作者：
Hudson, Thomas J.