Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis.
Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis.
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细胞毒性 T 淋巴细胞相关抗原 4 多态性与哮喘风险：荟萃分析
DOI：
10.1371/journal.pone.0042062
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Xiu Q
中科院分区：
文献类型：
--
作者：
Nie W;Chen J;Xiu Q
许多研究评估了细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因多态性与不同人群哮喘的关系。然而，结果是矛盾的。我们进行了一项荟萃分析，以检查CTLA-4多态性与哮喘易感性之间的关联。方法计算机检索Pubmed、EMBASE、HuGE Navigator、万方数据库。数据由两名审查员独立提取。比值比（OR）和95%置信区间（CI）用于评估关联的强度。结果共纳入17篇文献，涉及病例6378例，对照8674例。AA与AG+GG相比，+49 A/G多态性与哮喘有显著相关性（OR = 1.18，95%CI 1.01-1.37，P = 0.04）。 −318 C/T、−1147 C/T、CT60 A/G、−1722 C/T或rs 926169多态性与哮喘风险之间没有显著关联。结论CTLA-4基因+49 A/G多态性是哮喘的危险因素。
Background A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility. Methods Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Results Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01–1.37, P = 0.04). There were no significant associations between −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, or rs926169 polymorphisms and asthma risk. Conclusions This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.
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影响因子：
2.8
作者：
Jasek, Monika;Luszczek, Wioleta;Kusnierczyk, Piotr
通讯作者：
Kusnierczyk, Piotr
影响因子：
10.3
作者：
Jones, G;Wu, S;Stewart, G
通讯作者：
Stewart, G
影响因子：
4.2
作者：
Miyake, Yasuhiro;Ikeda, Fusao;Yamamoto, Kazuhide
通讯作者：
Yamamoto, Kazuhide
影响因子：
--
作者：
Anantharaman R;Andiappan AK;Nilkanth PP;Suri BK;Wang de Y;Chew FT
通讯作者：
Chew FT
影响因子：
5.3
作者：
Daley, Denise;Lemire, Mathieu;Hudson, Thomas J.
通讯作者：
Hudson, Thomas J.