The biology of fracture healing.
The biology of fracture healing.
复制标题
骨折愈合的生物学。
DOI：
10.1016/j.injury.2011.03.031
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发表时间：
2011-06
影响因子：
2.5
通讯作者：
Einhorn, Thomas A.
中科院分区：
文献类型：
--
作者：
Marsell, Richard;Einhorn, Thomas A.
关键词：
骨折愈合的生物学是一个复杂的生物学过程，遵循特定的再生模式，涉及数千个基因表达的变化。虽然仍然有很多要学习，以充分理解骨再生的途径，解剖和生物化学事件的整体途径已被彻底调查。这些努力提供了骨折愈合如何发生的一般理解。在最初的创伤之后，骨通过直接膜内或间接骨折愈合而愈合，其包括膜内和软骨内骨形成。最常见的途径是间接愈合，因为直接骨愈合需要解剖复位和刚性稳定条件，通常仅通过切开复位和内固定获得。然而，当达到这样的条件时，直接愈合级联允许骨结构立即再生解剖板层骨和哈弗系统，而无需任何必要的重塑步骤。在所有其他不稳定的条件下，骨愈合遵循特定的生物学途径。它涉及急性炎症反应，包括几种重要分子的产生和释放，以及间充质干细胞的募集以产生初级软骨愈伤组织。这种初级骨痂后来经历了血管再生和钙化，并最终重塑以完全恢复正常的骨结构。在这篇文章中，我们总结了骨折愈合的基础生物学。
The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been thoroughly investigated. These efforts have provided a general understanding of how fracture healing occurs. Following the initial trauma, bone heals by either direct intramembranous or indirect fracture healing, which consists of both intramembranous and endochondral bone formation. The most common pathway is indirect healing, since direct bone healing requires an anatomical reduction and rigidly stable conditions, commonly only obtained by open reduction and internal fixation. However, when such conditions are achieved, the direct healing cascade allows the bone structure to immediately regenerate anatomical lamellar bone and the Haversian systems without any remodeling steps necessary. In all other non-stable conditions, bone healing follows a specific biological pathway. It involves an acute inflammatory response including the production and release of several important molecules, and the recruitment of mesenchymal stem cells in order to generate a primary cartilaginous callus. This primary callus later undergoes revascularization and calcification, and is finally remodeled to fully restore a normal bone structure. In this article we summarize the basic biology of fracture healing.
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影响因子：
4.1
作者：
Bais, M. V.;Wigner, N.;Young, M.;Toholka, R.;Graves, D. T.;Morgan, E. F.;Gerstenfeld, L. C.;Einhorn, T. A.
通讯作者：
Einhorn, T. A.
影响因子：
6.2
作者：
Barnes, GL;Kostenuik, PJ;Einhorn, TA
通讯作者：
Einhorn, TA
影响因子：
2.8
作者：
BREUR, GJ;VANENKEVORT, BA;WILSMAN, NJ
通讯作者：
WILSMAN, NJ
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
影响因子：
6.2
作者：
Cho, TJ;Gerstenfeld, LC;Einhorn, TA
通讯作者：
Einhorn, TA