Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98.
Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98.
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DOI：
10.1155/2013/695179
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发表时间：
2013
影响因子：
--
通讯作者：
Jiang B
中科院分区：
文献类型：
--
作者：
Chen Z;Cheng Q;Ma Z;Xi H;Peng R;Jiang B
RAF-1激酶抑制蛋白(RKIP)是一种肿瘤和癌细胞中的转移抑制因子。MicroRNAs(MiRNAs)通过负性调控癌基因和肿瘤抑制因子，在肿瘤的发生和发展中发挥重要作用。最近，研究发现一些miRNAs通过调节转移相关基因来促进或抑制肿瘤的侵袭或转移，为抗转移策略提供了潜在的治疗靶点。在本研究中，我们发现RKIP和miR-98在脑胶质瘤组织中的表达明显低于正常脑组织。RKIP过表达上调了miR-98的表达，抑制了胶质瘤细胞的侵袭，抑制了miR-98靶基因HMGA2的表达，但对胶质瘤细胞的增殖无影响。此外，强制表达miR-98加速了对胶质瘤细胞侵袭的抑制，而HMGA2的表达对胶质瘤细胞的增殖也没有影响。我们的发现重新描述了RKIP/miR-98与HMGA2的连接，并为胶质瘤细胞的侵袭提供了潜在的机制。RKIP和miR-98可能说明信号通路信号的潜在治疗作用。
Raf-1 kinase inhibitor protein (RKIP) is a tumor and metastasis suppressor in cancer cells. MicroRNAs (miRNAs) have been suggested to play a vital role in tumor initiation and progression by negatively regulating oncogenes and tumor suppressors. Quite recently, studies have identified some miRNAs operating to promote or suppress tumor invasion or metastasis via regulating metastasis-related genes, providing potential therapeutic targets on antimetastasis strategy. In this study, we found that the expression of RKIP and miR-98 in glioma tissues were significantly lower than that in normal brain tissues. Overexpression of RKIP upregulated miR-98 expression and inhibited glioma cell invasion and miR-98 target gene HMGA2 but had no effect in glioma cell proliferation. Moreover, forced expression of miR-98 accelerated the inhibition of glioma cell invasion and the expression of HMGA2 also had no effect in glioma cell proliferation. Our findings newly described RKIP/miR-98 to HMGA2 link and provided a potential mechanism for glioma cell invasion. RKIP and miR-98 may illustrate the potential therapeutic utility of signaling pathway signatures.
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影响因子：
9
作者：
通讯作者：
--
高迁移率A2是头颈鳞状细胞癌中miRNA-98的靶标。
影响因子：
37.3
作者：
Hebert, Carla;Norris, Kathleen;Scheper, Mark A;Nikitakis, Nikolaos;Sauk, John J
通讯作者：
Sauk, John J
影响因子：
12.7
作者：
Claes A;Idema AJ;Wesseling P
通讯作者：
Wesseling P
影响因子：
11.5
作者：
Chatterjee, Devasis;Sabo, Edmond;Resnick, Murray B.
通讯作者：
Resnick, Murray B.
影响因子：
3.5
作者：
Martinho, Olga;Gouveia, Antonio;Lopes, Jose Manuel
通讯作者：
Lopes, Jose Manuel