Prevention and treatment of postmenopausal osteoporosis.
Prevention and treatment of postmenopausal osteoporosis.
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DOI：
10.1016/j.jsbmb.2013.09.008
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发表时间：
2014-07
影响因子：
4.1
通讯作者：
Gallagher, J. Christopher
中科院分区：
文献类型：
--
作者：
Tella, Sri Harsha;Gallagher, J. Christopher
一开始，也就是从20世纪60年代开始，当绝经和骨质疏松症之间的联系首次被确定时;雌激素治疗是预防骨质流失的标准，但是没有骨折数据，即使它被认为是有效的。这种情况一直持续到2001年的妇女健康倡议（WHI）研究，该研究发表了6年激素治疗的数据，显示心脏病发作和乳腺癌的增加。尽管风险很小，每年每1500名使用者中有1人，但患者仍然担心，雌激素的使用量大幅下降。在后来的分析中，WHI的研究表明，雌激素减少了50-60岁年龄组的骨折，实际上预防了心脏病发作。单独使用雌激素似乎比雌激素+醋酸甲羟孕酮更安全，实际上可以减少乳腺癌。
In the beginning, that is from the 1960's, when a link between menopause and osteoporosis was first identified; estrogen treatment was the standard for preventing bone loss, however there was no fracture data, even though it was thought to be effective. This continued until the Women's Health Initiative (WHI) study in 2001 that published data on 6 years of treatment with hormone therapy that showed an increase in heart attacks and breast cancer. Even though the risks were small, 1 per 1500 users annually, patients were worried and there was a large drop off in estrogen use. In later analyses the WHI study showed that estrogen reduced fractures and actually prevented heart attacks in the 50-60 year age group. Estrogen alone appeared to be safer to use than estrogen + the progestin medroxyprogesterone acetate and actually reduced breast cancer.
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影响因子：
158.5
作者：
Cummings, SR;Browner, WS;Ettinger, B
通讯作者：
Ettinger, B
影响因子：
158.5
作者：
Finkelstein, JS;Hayes, A;Neer, RM
通讯作者：
Neer, RM
影响因子：
120.7
作者：
Cummings, SR;Eckert, S;Jordan, VC
通讯作者：
Jordan, VC
影响因子：
6.2
作者：
Black, Dennis M.;Reid, Ian R.;Boonen, Steven;Bucci-Rechtweg, Christina;Cauley, Jane A.;Cosman, Felicia;Cummings, Steven R.;Hue, Trisha F.;Lippuner, Kurt;Lakatos, Peter;Leung, Ping Chung;Man, Zulema;Martinez, Ruvie Lou Maria;Tan, Monique;Ruzycky, Mary Ellen;Su, Guoqin;Eastell, Richard
通讯作者：
Eastell, Richard
影响因子：
6.2
作者：
Eastell, Richard;Nickelsen, Thomas;Glueer, Claus C.
通讯作者：
Glueer, Claus C.