Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome.
Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome.
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DOI：
10.5213/inj.1835062.531
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发表时间：
2018-01
影响因子：
2.3
通讯作者：
Andersson KE
中科院分区：
文献类型：
--
作者：
Birder L;Andersson KE
间质性膀胱炎/膀胱疼痛综合征（IC/BPS）的病因尚不明确，可能涉及多种原因。为了更好地了解其病理生理学，人们已经做出了许多努力来创建IC/BPS模型。大多数现有的IC/BPS模型都试图通过对健康动物施加有害的膀胱内或全身刺激来重建膀胱相关特征。这些模型有助于理解各种机制；然而，它们仅限于证明膀胱和神经系统如何对有害刺激作出反应，并不能代表IC/BPS的复杂相互作用和病理生理学。为了研究可能与IC/BPS相关的各种因素，至少常用3种不同类型的动物模型：(1)以膀胱为中心的模型，(2)机制复杂的模型，(3)心理和生理应激源/自然疾病模型。很明显，人类疾病的所有方面都不能用一个单一的模型来模拟。可能需要几个模型，每个模型都有助于拼图的一部分，以重建诊断为IC/BPS的疾病的病理生理学和时间进程的合理图景，从而确定合理的治疗目标。
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.
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