The immune system's involvement in obesity-driven type 2 diabetes.
The immune system's involvement in obesity-driven type 2 diabetes.
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DOI:
10.1016/j.smim.2012.12.001
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发表时间:
2012-12
影响因子:
7.8
通讯作者:
Mathis D
中科院分区:
文献类型:
--
作者:
Shu CJ;Benoist C;Mathis D
Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the crosstalk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
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