The Expression of Histamine Receptors in Skin Lesions of MRL/MPlpr/ lpr Mice
The Expression of Histamine Receptors in Skin Lesions of MRL/MPlpr/ lpr Mice
复制标题
MRL/MPlpr/lpr小鼠皮损中组胺受体的表达
DOI：
10.2174/1874372200802010083
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
F. Furukawa
中科院分区：
文献类型：
--
作者：
T. Yoshimasu;N. Kanazawa;Naoya Mikita;F. Furukawa
系统性红斑狼疮（SLE）是一种慢性炎症性疾病，伴全身脏器紊乱，包括皮肤改变。MRL/MP-lpr/lpr （MRL/l）小鼠是人LE模型。MRL/l小鼠皮肤病变表现出组胺- n -甲基转移酶（HMT）活性下降和组胺代谢受损。为了明确包括H1R、H2R和H3R在内的组胺受体（HRs）在MRL/l皮肤病变中的作用，采用免疫组织化学染色和RT-PCR方法评估HRs与皮肤病变的关系。2月龄（mo） MRL/l小鼠非病变皮肤中可见H2R的表达；H2R的表达持续了几个月，然后在5个月MRL/l小鼠的皮肤病变中下降。MRL/l皮肤病变中可见表达H2R的致密肥大细胞浸润。综上所述，MRL/l小鼠皮肤病变中肥大细胞中H2R表达的增加可能与组胺代谢有关。
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease accompanied with systemic organs dis- order including skin changes. The MRL/MP-lpr/lpr (MRL/l) mouse is a model of human LE. MRL/l mice skin lesions ex- hibit a decreased activity in histamine-N-methyltransferase (HMT) and impaired histamine metabolism. In order to clarify the role of histamine receptors (HRs) including H1R, H2R and H3R in MRL/l skin lesions, the relationship between HRs and skin lesions was assessed by immunohistochemical staining and RT-PCR methods. The expression of H2R was seen in the non-lesional skin of 2-month-old (mo) MRL/l mice; H2R expression continued for a couple of months, and then de- creased in the skin lesions of 5-mo MRL/l mice. In MRL/l skin lesions, a dense mast cell infiltration expressed H2R was seen. In conclusion, an increased expression of H2R in mast cells may be associated with histamine metabolism in skin le- sions from MRL/l mice.
小鼠狼疮模型皮肤病变的细胞因子谱
DOI：
--
发表时间：
2005
期刊：
J Dermatol Sci Suppl.1
影响因子：
--
作者：
T Nishide;T Yoshimasu;T Ikeda;N Seo;T Ohtani;F Furukawa
通讯作者：
F Furukawa
影响因子：
6.5
作者：
KANAUCHI, H;FURUKAWA, F;IMAMURA, S
通讯作者：
IMAMURA, S